[1]胡洋,毛丹,伍津正,等.甜梦口服液联合穴位贴敷治疗乳腺癌化疗后患者癌因性失眠临床研究[J].现代中医药,2023,(01):083-88.[doi:10.13424/j.cnki.mtcm.2023.01.016]
　HU Yang??MAO Dan??WU Jinzheng??FENG Lei.Clinical Observation of Tianmeng Oral Liquid Combined with Acupoint Application in Treatment of Cancerrelated Insomnia in Patients with Breast Cancer After Chemotherapy[J].Modern Traditional Chinese Medicine,2023,(01):083-88.[doi:10.13424/j.cnki.mtcm.2023.01.016]
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甜梦口服液联合穴位贴敷治疗乳腺癌化疗后患者癌因性失眠临床研究
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年01期
页码:
083-88
栏目:
临床研究
出版日期:
2023-01-20

文章信息/Info

Title:
Clinical Observation of Tianmeng Oral Liquid Combined with Acupoint Application in Treatment of Cancerrelated Insomnia in Patients with Breast Cancer After Chemotherapy
文章编号:
1672-0571(2023)01-0083-06
作者:
胡洋1; 毛丹1; 伍津正1; 冯磊2
1.中南大学湘雅二医院，湖南 长沙 410007；
2.湖南省中医药研究院附属医院，湖南 长沙 410006
Author(s):
HU Yang1??MAO Dan1??WU Jinzheng1??FENG Lei2?
1.Xiangya Second Hospital of Central South University，Changsha 410007,China；
2 Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006,China
关键词:
乳腺癌化疗后; 癌因性失眠; 甜梦口服液; 穴位贴敷
Keywords:
After chemotherapy for breast cancer; Cancerrelated insomnia; Tianmeng oral liquid; Acupoint application; Clinical efficacy
分类号:
R273?
DOI:
10.13424/j.cnki.mtcm.2023.01.016
文献标志码:
A??
摘要:
目的 观察甜梦口服液联合穴位贴敷治疗乳腺癌化疗后癌因性失眠患者（cancerrelated insomia，CRI）的临床疗效和安全性。方法 60例乳腺癌化疗后CRI患者随机分为对照组和观察组各30例，对照组予以艾司唑仑片口服，观察组予以甜梦口服液联合穴位贴敷治疗，共治疗8周。评估两组患者治疗前后的临床疗效、匹兹堡睡眠质量指数(Pittsburgh sleep quality index，PSQI)评分以及爱泼沃斯思睡量表（Epworth sleepiness scale，ESS）评分，同时观察两组患者的不良反应。结果 两组患者临床疗效比较，观察组总有效率明显高于对照组（P＜0.05）； PSQI评分比较，观察组睡眠效率及日间功能障碍评分较观察组下降明显（P＜0.05）；观察组治疗后困倦评分与对照组比较有显著差异（P＜0.05）；且观察组患者在治疗过程中不良反应的发生低于对照组（P＜005）。结论 甜梦口服液联合穴位贴敷能明显改善乳腺癌化疗后CRI患者的睡眠质量，缩短入眠时间，延长睡眠时间，改善睡眠障碍，尤其能提高患者的睡眠效率，改善日间功能障碍以及困倦状态，且安全性高，无明显不良反应，值得临床应用推广。
Abstract:
Objective To observe the clinical efficacy and safety of Tianmeng oral liquid combined with acupoint application in the treatment of cancer related insomnia (CRI) after chemotherapy for breast cancer.Methods 60 patients with CRI after chemotherapy for breast cancer were randomly divided into a control group and an observation group with 30 patients in each group.To evaluate the clinical efficacy，Pittsburgh sleep quality index (PSQI) score and Epworth sleep scale (ESS) score of the two groups before and after treatment，and observe the adverse reactions of the two groups of patients. Results The total effective rate of the observation group was significantly higher than that of the control group（P＜0.05）；Compared with the PSQI score，the sleep efficiency and daytime dysfunction score in the observation group decreased significantly (P<0.05)；There was a significant difference between the observation group and the control group（P＜0.05）；The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).Conclusion The combination of Tianmeng oral liquid and acupoint application can significantly improve the sleep quality of CRI patients after chemotherapy for breast cancer，shorten the time to sleep，prolong the time to sleep，improve sleep disorders，especially improve the sleep efficiency of patients，improve daytime dysfunction and drowsiness，and have high safety and no obvious adverse reactions，which is worthy of clinical application and promotion.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金青年项目（821015346）；湖南省自然科学基金青年项目（2020JJ5824）；湖南省中医药管理局面上项目（2021225）；湖南省中医药管理局面上项目（D2022087）；湖南省中医药研究院院级科研课题（202005）
更新日期/Last Update: 2023-01-20