[1]孔婧** 周秉舵 汤瑾 何聪 唐义爽 王晓素*** 潘旭娣 刘霞 季晶.清下化瘀方联合西医常规疗法 对中重度急性胰腺炎患者内毒素、 PCT、IL-6、IL-10的影响[J].现代中医药,2023,(05):063-68.[doi:10.13424/j.cnki.mtcm.2023.05.013]
　KONG JingZHOU Bingtuo TANG Jin HE Cong TANG Yishuang WANG Xiaosu PAN Xudi LIU Xia JI Jing.Effect of Qingxia Huayu Formula Combined with Conventional Western Medicine Therapy on Endotoxins， PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis[J].Modern Traditional Chinese Medicine,2023,(05):063-68.[doi:10.13424/j.cnki.mtcm.2023.05.013]
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清下化瘀方联合西医常规疗法 对中重度急性胰腺炎患者内毒素、 PCT、IL-6、IL-10的影响
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年05期
页码:
063-68
栏目:
出版日期:
2023-09-20

文章信息/Info

Title:
Effect of Qingxia Huayu Formula Combined with Conventional Western Medicine Therapy on Endotoxins， PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis
文章编号:
1672-0571(2023)05-0063-06
作者:
孔婧1; 2** 周秉舵1; 2 汤瑾1; 2 何聪1; 2 唐义爽1 王晓素1; 2*** 潘旭娣1 刘霞1 季晶1
1.上海中医药大学附属岳阳中西医结合医院，上海 200437；
2.上海中医药大学中西医结合消化病研究室，上海 200437
Author(s):
KONG Jing1; 2ZHOU Bingtuo1; 2 TANG Jin1; 2 HE Cong1; 2 TANG Yishuang1 WANG Xiaosu1; 2 PAN Xudi1 LIU Xia1 JI Jing1
1.Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200437,China；
2.Digestive Disease Research Laboratory of Integrated Traditional Chinese and Western Medicine，Shanghai 200437,China
关键词:
关键词：急性胰腺炎; 清下化瘀方; 内毒素; 降钙素原; 炎症介质
Keywords:
Key words:Acute pancreatitis; Qingxia Huayu formula; Endotoxins; Procalcitonin; Inflammatory mediators
分类号:
R256.39
DOI:
10.13424/j.cnki.mtcm.2023.05.013
文献标志码:
A
摘要:
摘 要：目的 观察清下化瘀方对急性胰腺炎患者内毒素、PCT、IL6、IL10的影响，明确其抗炎效果。方法 将60例MSAP或SAP患者分为治疗组30例，对照组30例，对照组给予西药常规治疗，治疗组在对照组的基础上加服清下化瘀方，两组均治疗7天后，通过内毒素、PCT、细胞因子（如IL6、IL10）等检测指标，以观察临床疗效。结果 与对照组比较，治疗组可显著降低AP患者肠源性内毒素水平、降钙素原水平、IL6水平（P＜0.01），两组对IL10水平影响无明显统计学意义（P＞0.05）。结论 早期联合清下化瘀方鼻饲减轻肠源性内毒素移位，减少炎症介质释放，减轻SIRS，降低MODS发生率。
Abstract:
Abstract：Objective To evaluate the effect of Qingxia Huayu formula on endotoxin，PCT，IL-6，and IL-10 in patients with acute pancreatitis，and to clarify its antiinflammatory effect.Methods Sixty MSAP or SAP patients were divided into a treatment group of 30 cases and a control group of 30 cases.The control group was treated with conventional Western medicine，while the treatment group was supplemented with Qingxia Huayu formula.After 7 days of treatment，both groups were tested for endotoxin，PCT，cytokines (such as IL-6 and IL-10) to observe clinical efficacy.Results Compared with the control group，the treatment group significantly reduced the levels of gut derived endotoxins，procalcitonin，and IL-6 in AP patients (P<0.01)，while the two groups had no statistically significant impact on IL-10 levels (P>0.05).Conclusion Early combination of Qingxia Huayu formula nasal feeding can reduce intestinal endotoxin translocation，reduce the release of inflammatory mediators，alleviate SIRS，and reduce the incidence of MODS.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金委员会青年项目（82004264）；上海市申康医院发展中心中西医临床协作试点建设项目（ZY2018-2020-FWTX-1004）
更新日期/Last Update: 2023-09-22