[1]张辉 王来法 王雪琴邓玲 崔艳慧.知母及其活性成分抗抑郁作用机制研究进展[J].现代中医药,2023,(06):001-7.[doi:10.13424/j.cnki.mtcm.2023.06.001]
　ZHANG HuiWANG Laifa WANG Xueqin DENG Ling CUI Yanhui.Research Progress on the Antidepressant Mechanism of Zhimu and Its Active Ingredients[J].Modern Traditional Chinese Medicine,2023,(06):001-7.[doi:10.13424/j.cnki.mtcm.2023.06.001]
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知母及其活性成分抗抑郁作用机制研究进展()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年06期
页码:
001-7
栏目:
出版日期:
2023-12-08

文章信息/Info

Title:
Research Progress on the Antidepressant Mechanism of Zhimu and Its Active Ingredients
文章编号:
1672-0571(2023)06-0001-07
作者:
张辉1 王来法1 王雪琴2邓玲2 崔艳慧1
1.长沙医学院 神经变性病基础与临床湖南省普通高等学校重点实验室，湖南 长沙 410000；
2.长沙医学院 湖南省新型药物制剂研究与开发重点实验室，湖南 长沙 410000
Author(s):
ZHANG Hui1WANG Laifa1 WANG Xueqin2 DENG Ling2 CUI Yanhui1
1.Key Laboratory of Neurodegenerative Disease Fundamentals and Clinical Practice in Hunan Province，ChangshaMedical College, Changsha 410000,China;
2.Hunan Provincial Key Laboratory of New Drug Formulation Researchand Development,Changsha Medical College, Changsha 410000,China
关键词:
关键词：知母; 活性成分; 抗抑郁; 作用机制; 研究进展
Keywords:
Key words:Zhimu; Active ingredients; Anti depression; Mechanism of action; Research progress
分类号:
R285.5
DOI:
10.13424/j.cnki.mtcm.2023.06.001
文献标志码:
A
摘要:
摘 要：抑郁症发病机制复杂，目前抗抑郁药物可以有效缓解症状，但不能根治，而且长期使用可能会出现一些副作用和依赖性。传统中药知母用于抑郁症的治疗由来已久。随着研究的深入，知母的活性成分知母总皂苷、知母皂苷B-Ⅱ、知母皂苷B-Ⅲ、菝葜皂苷元、薯蓣皂苷元、知母宁以及知母皂苷B-Ⅲ等陆续被鉴定和开发。知母的作用具有多靶点、多通路的特点，涉及了抗神经炎症、抗氧化应激、调节神经递质功能等机制，在抑郁症的治疗中展现出良好的潜力。结合文献，对知母及其活性成分抗抑郁作用机制的研究进展作以综述，以期为研究者深入探究知母抗抑郁作用机制提供参考。
Abstract:
Abstract：The pathogenesis of depression is complex.Currently, antidepressants can effectively alleviate symptoms.But it cannot be eradicated, and long-term use may lead to some side effects and dependence.The traditional Chinese medicine Zhimu has been used for the treatment of depression for a long time. With the deepening of research, the active components of Zhimu, including total saponins of Zhimu, saponins B-Ⅱ, saponins B-Ⅲ, saponins from Zhimu, diosgenins, saponins from Zhimu, and saponins B-Ⅲ from Zhimu have been identified and developed. The role of Zhimu has the characteristics of multiple targets and pathways, involving mechanisms such as anti neuroinflammation, antioxidant stress, and regulation of neurotransmitter function, demonstrating good potential in the treatment of depression. The article will provide a review of the research progress on the antidepressant mechanisms of Zhimu and its active ingredients, in order to provide reference for researchers to further explore the antidepressant effects of Zhimu.

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备注/Memo

备注/Memo:
基金项目：湖南省教育厅科研基金项目（22C0673）；湖南省自然科学基金项目（2023JJ30092，2021JJ40644）；长沙医学院2022年第一批ESI学科建设专项课题（2022CYY013）
更新日期/Last Update: 2023-11-23