[1]田申,李庆,王逍,等.化痰祛瘀汤联合康复治疗对缺血性中风偏瘫患者血清神经细胞因子、氧化应激及血液流变学的影响[J].现代中医药,2024,(01):062-67.[doi:10.13424/j.cnki.mtcm.2024.01.014]
 TIAN Shen,LI Qing,WANG Xiao,et al.A Study on the Serum Neurocytokines,Oxidative Stress,and Hemorheology of Ischemic Stroke Hemiplegia Patients treatedwith Huatan Quyu Decoction and Rehabilitation Therapy[J].Modern Traditional Chinese Medicine,2024,(01):062-67.[doi:10.13424/j.cnki.mtcm.2024.01.014]
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化痰祛瘀汤联合康复治疗对缺血性中风偏瘫患者血清神经细胞因子、氧化应激及血液流变学的影响()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年01期
页码:
062-67
栏目:
出版日期:
2024-01-20

文章信息/Info

Title:
A Study on the Serum Neurocytokines,Oxidative Stress,and Hemorheology of Ischemic Stroke Hemiplegia Patients treatedwith Huatan Quyu Decoction and Rehabilitation Therapy
文章编号:
1672-0571(2024)01-0062-06
作者:
田申李庆王逍谢福恒李沛赵丽萍
陕西中医药大学附属医院,陕西 咸阳 712000
Author(s):
TIAN ShenLI QingWANG XiaoXIE FuhengLI PeiZHAO Liping
Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China
关键词:
关键词:化痰祛瘀汤缺血性中风偏瘫康复治疗神经细胞离子氧化应激血液流变学
Keywords:
Key words:Huatan Quyu decoctionIschemic strokeHemiplegiaRehabilitation therapyNeurocytokinesOxidative stressHemorheology
分类号:
R255.2
DOI:
10.13424/j.cnki.mtcm.2024.01.014
文献标志码:
A
摘要:
摘要:目的 观察分析缺血性中风后偏瘫患者接受化痰祛瘀汤联合常规康复治疗对其血清神经细胞因子、氧化应激、血液流变学的影响。方法 收集2020年10月—2022年10月于我院进行治疗的缺血性中风后偏瘫患者90例,随机分为治疗组(45例,化痰祛瘀汤+常规康复治疗)、对照组(45例,常规康复治疗)。评估康复疗效,对比治疗前、治疗后组间肢体功能、血液流变学、血清氧化应激指标及神经细胞因子水平。结果 治疗组康复总有效率显著高于对照组(P<0.05);治疗后治疗组Fugl-Meyer运动功能评定量表(Fugl-Meyer Assessment,FMA)上肢、下肢评分均显著高于对照组(P<0.05);治疗后治疗组全血高切、低切黏度均显著低于对照组(P<0.05);治疗后治疗组血清丙二醛(malondialdehyde,MDA)水平低于对照组,超氧化物歧化酶(Superoxide dismutase,SOD)高于对照组(P<0.05);治疗后治疗组血清基质金属蛋白酶-9(matrix metalloproteinase.9,MMP-9)显著低于对照组,血管生成素1(angiopoietin-1,Ang-1)水平显著高于对照组(P<0.05);治疗后治疗组脑源性神经营养因子(brainderived neuro-trophic factor, BDNF)及神经生长因子(nerve growth factor, NGF)水平显著高于对照组(P<0.05)。结论 缺血性中风后偏瘫患者接受化痰祛瘀汤联合常规康复治疗疗效显著,可有效恢复患者肢体功能,其生效机制可能与改善患者血液流变学,减轻氧化应激反应,调节MMP-9、Ang-1水平及提高神经细胞因子水平有关。
Abstract:
Abstract:Objective To analyze the effects of Huatan Quyu decoction combined with conventional rehabilitation treatment on serum neurocytokines,oxidative stress,and hemorheology in patients with hemiplegia after ischemic stroke.Methods Ninety patients with post-stroke hemiplegia who underwent treatment in our hospital from October 2020 to October 2022 were randomly divided into a treatment group (45 cases,treated with Huatan Quyu decoction+conventional rehabilitation treatment) and a control group (45 cases,treated with conventional rehabilitation treatment).Evaluate rehabilitation efficacy,compare limb function,hemorheology,serum oxidative stress indicators,and neurocytokine levels between groups before and after treatment.Results The total effective rate of rehabilitation in the treatment group was significantly higher than that in the control group (P<0.05);After treatment,the Fugl Meyer Motor Function Assessment (FMA) scores of the upper and lower limbs in the treatment group were significantly higher than those in the control group (P<0.05);After treatment,the whole blood high shear and low shear viscosity in the treatment group were significantly lower than those in the control group (P<0.05);After treatment,the serum malondialdehyde (MDA) level in the treatment group was lower than that in the control group,and the superoxide dismutase (SOD) was higher than that in the control group (P<0.05);After treatment,the serum levels of matrix metalloproteinase-9 (MMP-9) in the treatment group were significantly lower than those in the control group,and the levels of angiopoietin-1 (Ang-1) were significantly higher than those in the control group (P<0.05);After treatment,the levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the treatment group were significantly higher than those in the control group (P<0.05).Conclusion The combination of Huatan Quyu decoction and conventional rehabilitation therapy has a significant therapeutic effect on hemiplegia patients after ischemic stroke,which can effectively restore limb function.The effective mechanism may be related to improving the patients hemorheology,reducing oxidative stress response,regulating MMP-9 and Ang-1 levels,and increasing the level of neurocytokines.

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备注/Memo

备注/Memo:
基金项目:陕西省创新能力支撑计划(2017KCT-26);陕西省教育厅重点科学研究计划项目(20js037;20js038)
更新日期/Last Update: 2024-01-27