[1]郑美娥熊彦凌康徐瑞唐群廖海燕**孟斌黎湘黄雷.Caspase-3介导的细胞凋亡与细胞焦亡在肝细胞癌的作用及其中药治疗的研究进展[J].现代中医药,2024,(04):001-6.[doi:10.13424/j.cnki.mtcm.2024.04.001]
　ZHENG MeieXIONG YanlingKANG XuruiTANG QunLIAO HaiyanMENG Bin LXiang HUANG Lei.Role of Caspase-3 Mediated Cell Apoptosis and Cell Pyroptosisin Hepatocellular Carcinoma and Research Progress ofTraditional Chinese Medicine Treatment[J].Modern Traditional Chinese Medicine,2024,(04):001-6.[doi:10.13424/j.cnki.mtcm.2024.04.001]
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Caspase-3介导的细胞凋亡与细胞焦亡在肝细胞癌的作用及其中药治疗的研究进展()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年04期
页码:
001-6
栏目:
出版日期:
2024-08-28

文章信息/Info

Title:
Role of Caspase-3 Mediated Cell Apoptosis and Cell Pyroptosisin Hepatocellular Carcinoma and Research Progress ofTraditional Chinese Medicine Treatment
文章编号:
1672-0571(2024)04-0001-06
作者:
郑美娥1熊彦凌11康徐瑞1唐群1廖海燕1**孟斌1黎湘1黄雷2
1.湖南中医药大学，湖南 长沙 410208；
2.湖南中医药大学第一附属医院，湖南 长沙 410007
Author(s):
ZHENG Mei’e1XIONG Yanling1KANG Xurui1TANG Qun1LIAO Haiyan1MENG Bin1 L1Xiang1 HUANG Lei2
1.Hunan University of Chinese Medicine, Changsha 410208, China;
2.The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007,China
关键词:
关键词：Caspase-3; 细胞凋亡; 细胞焦亡; 肝细胞癌; 中药
Keywords:
Key words:Caspase-3;  Cell apoptosis;  Cell pyroptosis;  Hepatocellular carcinoma;  Traditional Chinese medicine
分类号:
R273
DOI:
10.13424/j.cnki.mtcm.2024.04.001
文献标志码:
A
摘要:
摘 要：细胞凋亡与细胞焦亡是两种重要的程序性细胞死亡方式，而半胱氨酸蛋白酶-3（Caspase-3）在这两种死亡方式中都扮演着重要的角色，其参与了内源性、外源性途径介导的细胞凋亡以及Caspase-3/GSDME依赖性细胞焦亡，在肝细胞癌（hepatocellular carcinoma,HCC）的治疗中起到了至关重要的作用。近年来，通过Caspase-3介导细胞凋亡及细胞焦亡治疗肝细胞癌的中药研究文献不断增加，在为肝细胞癌治疗提供思路方面具有巨大潜力。文章就Caspase-3介导的细胞凋亡与焦亡在肝细胞癌的作用及其在中药治疗方面的研究成果作一综述，以期为肝细胞癌的治疗和药物研究提供帮助。
Abstract:
Abstract：Apoptosis and cell pyroptosis are two important programmed cell death modes, and cysteine protease-3 (Caspase-3) plays an important role in both of these death modes. It participates in endogenous and exogenous pathways mediated cell apoptosis and Caspase-3/GSDME dependent cell pyroptosis, playing a crucial role in the treatment of hepatocellular carcinoma (HCC). In recent years, there has been a continuous increase in research literature on traditional Chinese medicine for the treatment of hepatocellular carcinoma through Caspase-3 mediated cell apoptosis and cell pyroptosis, which has great potential in providing ideas for the treatment of hepatocellular carcinoma. This article provides a review of the role of Caspase-3 mediated cell apoptosis and pyroptosis in hepatocellular carcinoma, as well as the research achievements in traditional Chinese medicine treatment, in order to provide assistance for the treatment and drug research of hepatocellular carcinoma.

参考文献/References:

［1］SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA:a Cancer Journal for Clinicians,2021,71(3):209-249.
? [2］蒋兵,杨韬,封龙飞,等.红景天苷对HepG2细胞增殖、迁移、侵袭及凋亡的影响［J］.中国实验方剂学杂志,2022,28(17):75-83.
［3］PISTRITTO G,TRISCIUOGLIO D,Ceci C,et al.Apoptosis as anticancer mechanism:function and dysfunction of its modulators and targeted therapeutic strategies［J］.Aging,2016,8(4):603-619.
［4］JAN R,CHAUDHRY GES.Understanding apoptosis and apoptotic pathways targeted cancer therapeutics［J］.Advanced Pharmaceutical Bulletin,2019,9(2):205-218.
［5］YU P,ZHANG X,LIU N,et al.Pyroptosis:mechanisms and diseases［J］.Signal Transduction and Targeted Therapy,2021,6:128.
［6］常钰玲,牛亚倩,陈彻.细胞焦亡及其在肝细胞癌中作用的研究进展［J］.中国生物制品学杂志,2023,36(1):124-127.
［7］杨忠信,黄志昂,潘丽红,等.TPX2对人肺癌细胞增殖、凋亡及cleaved caspase-3表达的影响［J］.中华解剖与临床杂志,2018,23(2):155-159.
［8］VAN OPDENBOSCH N,LAMKANFI M.Caspases in cell death,inflammation,and disease［J］.Immunity,2019,50(6):1352-1364.
［9］LI LJ,WANG SM,ZHOU WH.Balance cell apoptosis and pyroptosis of caspase-3-activating chemotherapy for better antitumor therapy［J］.Cancers,2022,15(1):26.
［10］程雪赟,原大江.半胱氨酸-天冬氨酸蛋白酶参与细胞凋亡的机制与进展［J］.临床医药实践,2018,27(8):616-620.
［11］BHOLA PD,LETAI A.Mitochondria-judges and executioners of cell death sentences［J］.Molecular Cell,2016,61(5):695-704.
［12］KALKAVAN H,GREEN DR.MOMP,cell suicide as a BCL-2 family business［J］.Cell Death and Differentiation,2018,25(1):46-55.
［13］SHI M,TANG C,Wu JX,et al.Mass spectrometry detects sphingolipid metabolites for discovery of new strategy for cancer therapy from the aspect of programmed cell death［J］.Metabolites,2023,13(7):867.
［14］李先佳,任丽平,金少举.马鞭草总黄酮对肝癌HepG-2细胞凋亡的影响机制研究［J］.现代预防医学,2017,44(15):2813-2816,2822.
［15］CHAO X,WANG GQ,TANG YP,et al.The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells［J］.PLoS One,2019,14(1):e0201864.
［16］SHANG N,BANK T,DING XZ,et al.Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death,compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation［J］.Cell Death & Disease,2018,9(5):558.
［17］WANG WT,ZHU MY,XU ZX,et al.Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity［J］.Biological Research,2019,52(1):36.
［18］HAN R,CHEN XY,LI Y,et al.MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating E2F1,E2F3,and caspase-3［J］.Cancer Management and Research,2019,11:2963-2976.
［19］LALIER L,VALLETTE F,MANON S.Bcl-2 family members and the mitochondrial import machineries:the roads to death［J］.Biomolecules,2022,12(2):162.
［20］WANG AL,JIANG HH,LIU YY,et al.Rhein induces liver cancer cells apoptosis via activating ROS-dependent JNK/Jun/caspase-3 signaling pathway［J］.Journal of Cancer,2020,11(2):500-507.
［21］ALAFNAN A,ALAMRI A,ALANAZI J,et al.Farnesiferol C exerts antiproliferative effects on hepatocellular carcinoma HepG2 cells by instigating ROS-dependent apoptotic pathway［J］.Pharmaceuticals,2022,15(9):1070.
［22］蒋参,熊慧生,巫桁锞,等.金丝桃苷介导P53/Caspase通路对人肝癌HepG2细胞增殖和凋亡的调节作用［J］.中国免疫学杂志,2018,34(12):1832-1836.
［23］陈燕妮,王兰兰,查青,等.贝参茱萸方抑制H22肝癌模型小鼠肿瘤生长的作用及其分子机制［J］.环球中医药,2020,13(12):2011-2016.
［24］浦洪琴,韦鹏涯,韦星,等.中药抗癌灵诱导人肝癌SMMC-7721细胞凋亡及其机制研究［J］.中国老年学杂志,2009,29(3):288-290.
［25］赵家荣,冯雪松,李宏,等.四逆散对人肝癌HepG2细胞增殖、凋亡的影响及其机制［J］.中国应用生理学杂志,2020,36(5):489-493.
［26］WAN CR,CHEN YP,YIN P,et al.Transport stress induces apoptosis in rat myocardial tissue via activation of the mitogen-activated protein kinase signaling pathways［J］.Heart and Vessels,2016,31(2):212-221.
［27］KESAVARDHANA S,MALIREDDI RKS,KANNEGANTI TD.Caspases in cell death,inflammation,and pyroptosis［J］.Annual Review of Immunology,2020,38:567-595.
［28］RAMIREZ MLG,SALVESEN GS.A primer on caspase mechanisms［J］.Seminars in Cell & Developmental Biology,2018,82:79-85.
［29］姬菩忠,杨艳丽.GSDME引起的细胞焦亡在肿瘤治疗中的研究进展［J］.现代肿瘤医学,2022,30(16):3024-3027.
［30］王锐,付萍.细胞焦亡的发生机制研究［J］.医学信息,2021,34(11):43-46.
［31］SANTOS JC,DICK MS,LAGRANGE B,et al.LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation［J］.The EMBO Journal,2018,37(6):e98089.
［32］MAO XX,LI J,XIE X,et al.Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells［J］.Archives of Toxicology,2022,96(11):3091-3112.
［33］LIAO XX,DAI YZ,ZHAO YZ,et al.Gasdermin E:a prospective target for therapy of diseases［J］.Frontiers in Pharmacology,2022,13:855828.
［34］LI YQ,PENG JJ,PENG J,et al.The deafness gene GSDME:its involvement in cell apoptosis,secondary necrosis,and cancers［J］.Naunyn-Schmiedeberg’s Archives of Pharmacology,2019,392(9):1043-1048.
［35］MONTERO J,SAROSIEK KA,DEANGELO JD,et al.Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy［J］.Cell,2015,160(5):977-989.
［36］LI Y,SHI Y,CHEN J,et al.Association of polymorphisms in interleukin-18 and interleukin-28B with hepatitis B recurrence after liver transplantation in Chinese Han population［J］.International Journal of Immunogenetics,2012,39(4):346-352.
［37］宋伟.索拉非尼联合RSL3抗肝癌作用与GSDME介导的焦亡关系初步研究［D］.南宁:广西医科大学,2020.
［38］李伟,乔云,姚鹏宇.中药有效成分干预细胞焦亡发挥抗癌作用［J］.中医学报,2024,39(2):310-318.
［39］GALLUZZI L,KROEMER G.Secondary necrosis:accidental No more［J］.Trends in Cancer,2017,3(1):1-2.
［40］何欢欢,宋新强,王帅.细胞焦亡在癌症发生发展及治疗中作用的研究进展［J］.中国药理学与毒理学杂志,2022,36(7):536-543.
［41］常钰玲,牛亚倩,陈彻.细胞焦亡及其在肝细胞癌中作用的研究进展［J］.中国生物制品学杂志,2023,36(1):124-127.
［42］程希,周淑萍,何杰.雷公藤甲素对GSDME依赖性肝癌细胞焦亡的影响［J］.中医药导报,2021,27(2):8-11.
［43］LI YR,ZHAO RS,XIU ZR,et al.Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal［J］.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2023,116:154869.
［44］LIANG WF,GONG YX,LI HF,et al.Curcumin activates ROS signaling to promote pyroptosis in hepatocellular carcinoma HepG2 cells［J］.In Vivo,2021,35(1):249-257.
［45］SUN XF,ZHONG X,MA WF,et al.Germacrone induces caspase-3/GSDME activation and enhances ROS production,causing HepG2 pyroptosis［J］.Experimental and Therapeutic Medicine,2022,24(1):456.
［46］SONG AP,DING TT,WEI N,et al.Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity［J］.Toxicology and Applied Pharmacology,2023,472:116574.
［47］JIANG MX,QI L,LI LS,et al.The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer［J］.Cell Death Discovery,2020,6:112.
［48］纪凌云,吴俏兰,陈泽涛,等.基于NLRP3炎症小体介导的巨噬细胞焦亡探究黄芩-黄连对动脉粥样硬化的干预机制［J］.中国实验方剂学杂志,2024,30(7):121-130.

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备注/Memo

备注/Memo:
基金项目：湖南省自然科学基金项目（2021JJ30506）；湖南省卫生健康委科研重点项目（C202203108338）；湖南中医药大学大学生创新创业训练项目（1008058/9982）；湖南中医药大学重点培育学科基础医学学科资助（校行发规字【2023】2号）
更新日期/Last Update: 2024-07-15