[1]李华 郭婕 亢恺雯 路小伟 李智智 白呦呦 王强.近十年咖啡因对帕金森病的神经保护机制研究分析[J].现代中医药,2022,1(02):001-5.[doi:10.13424/j.cnki.mtcm.2022.02.001]
　LI Hua GUO Jie KANG Kaiwen LU Xiaowei LI Zhizhi BAI Youyou WANG Qiang.Research Progress of Neuroprotective Mechanism of Caffeine on Parkinson's Disease in Recent Ten Years[J].Modern Traditional Chinese Medicine,2022,1(02):001-5.[doi:10.13424/j.cnki.mtcm.2022.02.001]
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近十年咖啡因对帕金森病的神经保护机制研究分析
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年02期
页码:
001-5
栏目:
述评
出版日期:
2022-04-16

文章信息/Info

Title:
Research Progress of Neuroprotective Mechanism of Caffeine on Parkinson's Disease in Recent Ten Years
文章编号:
1672-0571(2022)02-0001-05
作者:
李华1 郭婕2 亢恺雯2 路小伟1 李智智1 白呦呦1 王强1; 3; 4
1.陕西中医药大学针灸推拿学院，陕西 咸阳 712046；
2.陕西中医药大学第二临床医学院，陕西 咸阳 712046；
3.陕西省针药结合重点实验室，陕西 咸阳 712046；
4.咸阳市神经生物学（针灸）重点实验室，陕西 咸阳 712046
Author(s):
LI Hua1 GUO Jie2 KANG Kaiwen2 LU Xiaowei1 LI Zhizhi1 BAI Youyou1 WANG Qiang1; 3; 4
1.College ofAcupuncture and Massage，Shaanxi University of Traditional Chinese Medicine，Shaanxi Xianyang 712046,China;
2.Second Clinical Medical School，Shaanxi University of Traditional Chinese Medicine，Shaanxi Xianyang 712046,China；
3.Shaanxi Key Laboratory of Acupuncture and Medicine，Shaanxi Xianyang 712046,China；
4.Xianyang Key Laboratory of Neurobiology (Acupuncture),Shaanxi Xianyang 712046,China
关键词:
关键词：咖啡因; 帕金森病; 神经保护; 神经退行性疾病; 中医药成分
Keywords:
Key words：Caffeine; Parkinson's disease; Neuroprotection; Neurodegenerative diseases; Components of traditional Chinese Medicine
分类号:
R259
DOI:
10.13424/j.cnki.mtcm.2022.02.001
文献标志码:
A
摘要:
摘 要：目的 分析近十年咖啡因对帕金森病（Parkinson's disease,PD）的神经保护机制，为有效防治PD提供多靶点。方法 检索万方、中国知网、PubMed、OVID等数据库，检索字段主要包括Caffeine、PD、神经保护、病理机制、中药成分等。结果 PD属于神经退行性疾病，其病理机制复杂，药物对其的使用仍局限，咖啡因对PD具有反向作用已得以证实。结论 咖啡因对PD具有神经保护机制，积极探索将咖啡因与中医药有效成分相结合进而延缓PD的发生和进展。
Abstract:
Abstract：Objective To analyze the neuroprotective mechanism of caffeine on Parkinson's disease (PD) in recent ten years，and to provide multiple targets for the effective prevention and treatment of PD.Methods Wanfang，CNKI，PubMed，OVID and other databases were searched.The search fields mainly included caffeine，PD，neuroprotection，pathological mechanism，traditional Chinese medicine components and so on.Results PD belongs to neurodegenerative disease，its pathological mechanism is complex，the use of drugs is still limited，and the reverse effect of caffeine on PD has been confirmed.Conclusion Caffeine has neuroprotective mechanism on PD.We should actively explore the combination of caffeine and effective components of traditional Chinese medicine，so as to delay the occurrence and progress of PD.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（81674086）；陕西省自然科学基础研究计划（2020JM-594）；陕西中医药大学经脉-脏腑相关研究创新团队（YL-09)
更新日期/Last Update: 2022-04-08