[1]文颖娟 陈茉 赵欢 陈丽娟 王江.脾主肌肉”与“线粒体质量控制”相关性研究[J].现代中医药,2022,1(03):001-8.[doi:10.13424/j.cnki.mtcm.2022.03.001]
　WEN Yingjuan CHEN Mo ZHAO Huan CHEN Lijuan WANG Jiang.Study on Correlation Between “Spleen Governing Muscle” and “Mitochondrial Quality Control”[J].Modern Traditional Chinese Medicine,2022,1(03):001-8.[doi:10.13424/j.cnki.mtcm.2022.03.001]
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脾主肌肉”与“线粒体质量控制”相关性研究
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年03期
页码:
001-8
栏目:
出版日期:
2022-06-10

文章信息/Info

Title:
Study on Correlation Between “Spleen Governing Muscle” and “Mitochondrial Quality Control”
文章编号:
1672-0571(2022)03-0001-08
作者:
文颖娟 陈茉 赵欢 陈丽娟 王江
陕西中医药大学，陕西 咸阳 712046
Author(s):
WEN Yingjuan CHEN Mo ZHAO Huan CHEN Lijuan WANG Jiang
Shaanxi University of Chinese Medicine，Shaanxi Xianyang 712046,China
关键词:
关键词：脾主肌肉; 重症肌无力; 葛根; 配伍; 线粒体质量控制
Keywords:
Key words：Spleen governing muscle; Myasthenia gravis; Pueraria lobata
分类号:
R228
DOI:
10.13424/j.cnki.mtcm.2022.03.001
文献标志码:
A
摘要:
摘 要：在“脾-肌肉-线粒体”研究基础上，从重症肌无力(Myasthenia gravis,MG)病理以线粒体功能失常为关键点，基于“脾主肌肉”，结合中医学“痿证”以脾虚为本、虚实夹杂的病机特点，延伸研究“脾-肌肉-线粒体质量控制”，而线粒体质量控制源于骨骼肌干细胞，受制于线粒体自身动态调节，故探讨葛根及其配伍可能通过两个层次调节线粒体质量，治疗MG：其一，在形成更多优质线粒体层面，从骨骼肌干细胞为切入，通过肌肉转录调节因子（myoblastdetermining，Myod）与Pax7动态调节以及P38 MAPK、AMPK信号通路激活，保护正常MSCs增殖，保障骨骼肌再生修复，使优质线粒体生成有源；其二，在线粒体自身动态调节层面，以线粒体生物合成、融合与分裂、自噬以及细胞内钙调节为主，形成线粒体活力的高度动态的可塑性网络，保证优质线粒体充满生机。
Abstract:
Abstract：Based on the research of “spleen-muscle-mitochondria”，from the pathology of myasthenia gravis （MG），taking mitochondrial dysfunction as the key point，based on “spleen governing muscle”，combined with the pathogenesis characteristics of “flaccidity syndrome” in traditional Chinese medicine，which is based on spleen deficiency and mixed with deficiency and excess，extend the research on “spleen-muscle-mitochondria quality control”，and the mitochondrial quality control originates from skeletal muscle stem cells and is subject to the dynamic regulation of mitochondria，Therefore，Pueraria lobata and its compatibility may regulate the quality of mitochondria and treat myasthenia gravis through two levels:First，at the level of forming more high-quality mitochondria，starting from skeletal muscle stem cells，through the dynamic regulation of Myod and Pax7 and the activation of P38 MAPK and AMPK signal pathway，protect the proliferation of normal MSCs，ensure the regeneration and repair of skeletal muscle and make high-quality mitochondria active；Second，at the level of dynamic regulation of mitochondria，it mainly focuses on mitochondrial biosynthesis，fusion and division，autophagy and intracellular calcium regulation，forming a highly dynamic plasticity network of mitochondrial vitality to ensure that high-quality mitochondria are full of vitality.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（81202642）；陕西省科学技术厅项目（2017SF-323）；第四批全国中医（临床、基础）优秀人才研修项目（国中医药人教发［2017］24号）；2021年度陕西中医药大学校级科研课题（国家基金培育面上项目6）
更新日期/Last Update: 2022-05-30