[1]胡倩 李丽梅 王兴强 王为 张春燕 汤小虎.基于网络药理学探析白芍-甘草治疗强直性脊柱炎作用机制[J].现代中医药,2022,1(04):032-38.[doi:10.13424/j.cnki.mtcm.2022.04.007]
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基于网络药理学探析白芍-甘草治疗强直性脊柱炎作用机制
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年04期
页码:
032-38
栏目:
方药纵横
出版日期:
2022-07-22

文章信息/Info

文章编号:
1672-0571(2022)04-0032-07
作者:
胡倩1 李丽梅1 王兴强2 王为1 张春燕1 汤小虎12
1.云南中医药大学,云南 昆明 650500;
2.云南中医药大学第一附属医院,云南 昆明 650032
关键词:
关键词:强直性脊柱炎缓急止痛炎症机制白芍甘草
分类号:
R285.6
DOI:
10.13424/j.cnki.mtcm.2022.04.007
文献标志码:
A
摘要:
摘?要: 目的 运用网络药理学技术研究白芍-甘草治疗强直性脊柱炎的可能作用机制。方法 通过检索TCMSP数据库获取中药的化学成分信息和潜在靶点;疾病靶点由GeneCards、OMIM、TTD、DrugBank、PharmGKb数据库得到;借助cytoscape软件绘制“中药-化合物-靶点”网络;使用STRING在线平台下载靶点相互作用数据、挖掘其核心靶点;运用Bioconductor平台和R语言对药物活性成分潜在靶点网络中的蛋白进行GO和KEGG分析。结果 筛选出87个药物有效成分共涉及80个关键靶点,根据degree值展示其主要成分:槲皮素、山柰酚、柚皮素等,关键靶点包括肿瘤坏死因子、白细胞介素6等。GO功能和KEGG通路分析获得主要通路为IL-17信号通路、TNF信号通路、NF-κB信号通路等。结论 本研究从网络药理学角度预测了白芍-甘草治疗强直性脊柱炎可能的主要成分、相关靶点及信号通路,以期为后续机制研究奠定了一定的基础。

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备注/Memo

备注/Memo:
基金项目:国家中医药管理局国家中医(类风湿关节炎)临床研究基地建设项目(国中医药科技函)〔2018〕131号;云南省中医(风湿病)临床医学研究中心项目(202102AA310006);国家中医药管理局重大疑难疾病中西医临床协作试点项目(国中医药办医政发〔2018〕3号);云南省“万人计划”名医专项(云卫人发〔2019〕1号)
更新日期/Last Update: 2022-08-03