[1]赵亚萍 杨丽霞 甘德成 朱向东 梁永林.基于肠道菌群探讨葛根芩连汤治疗湿热型2型糖尿病研究进展*[J].现代中医药,2023,(02):001-7.[doi:10.13424/j.cnki.mtcm.2023.02.001]
　ZHAO Yaping ?YANG Lixia ?GAN Decheng ?ZHU Xiangdong ?LIANG Yonglin.Research Progress of Gegen Qinlian Decoction in Treatment ofDamp Heat Type 2 Diabetes Based on Intestinal Flora[J].Modern Traditional Chinese Medicine,2023,(02):001-7.[doi:10.13424/j.cnki.mtcm.2023.02.001]
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基于肠道菌群探讨葛根芩连汤治疗湿热型2型糖尿病研究进展*
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年02期
页码:
001-7
栏目:
出版日期:
2023-04-19

文章信息/Info

Title:
Research Progress of Gegen Qinlian Decoction in Treatment ofDamp Heat Type 2 Diabetes Based on Intestinal Flora
文章编号:
1672-0571(2023)02-0001-07
作者:
赵亚萍 1杨丽霞 2甘德成 3 朱向东 4梁永林 1
1.甘肃中医药大学，甘肃 兰州730000；
2.甘肃省中医药研究院，甘肃 兰州730050；
3.甘肃省中医院，甘肃 兰州 730050；
4.宁夏医科大学 宁夏银川 750004
Author(s):
ZHAO Yaping 1?YANG Lixia 2?GAN Decheng 3?ZHU Xiangdong 4?LIANG Yonglin 1
1.Gansu University of Chinese Medicine,Lanzhou 730000,China;
2.Gansu Academy of Chinese Medicine,Lanzhou 730050,China;
3.Gansu Province Chinese Medicine Hospital,Lanzhou 730050,China;
4.Ningxia Medical University,Yinchuan 750004,China
关键词:
关键词：肠道菌群; 葛根芩连汤; 湿热证; 2型糖尿病; 胰岛素抵抗
Keywords:
Key words:Intestinal flora; Gegen Qinlian Decoction; Damp heat syndrome; Type 2 diabetes; Insulin resistance
分类号:
R255.4
DOI:
10.13424/j.cnki.mtcm.2023.02.001
文献标志码:
A
摘要:
摘 要： 近年来世界范围内2型糖尿病(Diabetes Mellitus type 2，T2DM)的发病率不断上升。微生态学研究证实，T2DM疾病的发生与肠道菌群数量及比例的失调有很大的关联性，这成为研究热点。现有实验发现：肠道菌群紊乱可通过短链脂肪酸学说、胆汁酸代谢学说、内毒素学说、支链氨基酸学说等机制来影响T2DM的发生发展。湿热证T2DM患者在临床最为常见，该类患者胰岛素抵抗最为严重，而动物实验研究发现葛根芩连汤可通过特定的分子机制及通路作用于肠道菌群，通过调节胰岛β细胞的功能、提高胰岛素敏感性、减轻氧化应激反应，从而调节血糖，减轻胰岛素抵抗，为临床治疗T2DM患者提供更科学的依据。但由于菌群数量庞杂，现有数据多偏重于动物实验，且研究菌群特异性不足，为此今后需进一步加强对T2DM特定菌群的研究，以及增加临床大样本数据统计。
Abstract:
Abstract：In recent years,the incidence rate of type 2 diabetes (T2DM) is increasing worldwide.Microbiology research has confirmed that the occurrence of its disease is closely related to the imbalance of the number and proportion of intestinal flora,and has become a research hotspot.Existing experiments have found that intestinal flora disorder can affect the occurrence and development of T2DM through the mechanism of short chain fatty acid theory,bile acid metabolism theory,endotoxin theory,branched chain amino acid theory,etc.Damp-heat syndrome is the most common syndrome type in T2DM patients,and insulin resistance is the most serious in this type of patients.Animal experimental studies have found that Gegen Qinlian Decoction can act on intestinal flora through specific molecular mechanisms and pathways,regulate the function of β cells of pancreas islets,improve insulin sensitivity,reduce oxidative stress reaction for regulating blood glucose and reducing insulin resistance,providing a more scientific basis for clinical treatment of T2DM patients.However,due to the large and complex number of flora,the existing data are mostly focused on animal experiments,and the specificity of the research flora is insufficient.Therefore,in the future,it is necessary to further strengthen the research on the specific flora of the disease and increase the statistics of clinical large sample data.

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备注/Memo

备注/Memo:
基金项目：甘肃省教育厅产业支撑计划项目（2021CYZC-03）；甘肃省教育科技创新项目产业支撑计划项目（2021CYZC-03）
更新日期/Last Update: 2023-03-27