[1] Ren Sisi Gao Ruhong,.Effect of Qingbai Santan Embrocation on the Therapeutic Effect of Vitiligo Model in Guinea Pigs and SOD Activity in Skin Lesions [J]. Modern Traditional Chinese Medicine, 2018, (04): 106-108. [doi: 10．13424/j．cnki．mtcm．2018．04．034]
Effect of Qingbai Santan Embrocation on the Therapeutic Effect
of Vitiligo Model in Guinea Pigs and SOD Activity in Skin Lesions
- Article number:
- 1672－0571(2018)04－0106－04
- Keywords:
- vitiligo; Qingbai Santan Embrocation; SOD
- ZTFLH:
- R285. 5
- Code:
- A
- Abstract:
- Objective: To investigate the curative effect of Qingbai Santan Embrocation on guinea pigs with vitiligo induced by hydroquinone and the SOD activity of skin lesions． Method: The vitiligo model was applied with 5% hydroquinone on the polled skin of the black guinea pigs． The experiment was set up in the normal group，the model group，the Qingbai Santan Embrocation group，and the compound kaliganran group． The Qingbai Santan Embrocation group was given the Hui medicine: Qingbai Santan Embrocation，the compound calorie group was given compound kaliganran，the normal group and the white model group were treated with saline，and each group had partial external applies for twice a day for 60 days． The curative effect was then observed and the SOD activity in skin lesions of guinea pigs was detected． Result: Guinea pigs in model group showed obvious pigmentation，and their skin was mostly pale spots，or white hair was present． In each treatment group，the skin on dorsal model site gradually darkened，and the color was brownish black with a small amount of pigmentation with obvious compound color． The levels of SOD in skin lesions of guinea pigs in the Qingbai Santan Embrocation group and the compound kaliranran group were significantly lower than those in the model group ( P ＜ 0． 05) ． TheQingbai Santan Embrocation group and the compound kaliranran group tend to be normal． Conclusion: The Qingbai Santan Embrocation has a good therapeutic effect on the experimental vitiligo guinea pig models． The mechanism of the treatment of vitiligo may be related to the reduction of the abnormal SOD activity in the skin lesion of vitiligo and make it tend to be normal．
References:
[1]张兰兰，闫明，刘晓东，霍仕霞． 两种化学脱色剂对两种
动物模拟白癜风作用比 较［J]． 医 药 导 报，2009，28
( 6) : 690 － 692．
[2]Schallreuter K U，Wood J M，Berger J． Low catalase levels
in the epidermis of patients with vitiligo．［J]． The Journal
of investigative dermatology，1991，97( 6) : 1081 － 1085．
[3]Schallreuter K U，Moore J，Wood J M，Beazley W D，Gaze D C，Tobin D J，Marshall H S，Panske
A，Panzig E，Hibberts N A． In vivo and in vitro evidence for
hydrogen peroxide ( H2O2 ) accumulation in the epidermis
of patients with vitiligo and its successful removal by a
UVB － activated pseudocatalase．［J]． The journal of inves tigative dermatology． Symposium proceedings / the Society
for Investigative Dermatology，Inc．［and]European Society
for Dermatological Research，1999，4( 1) : 91 － 96．
[4]Agrawal Deepali，Shajil E M，Marfatia Y S，Begum Rashee dunnisa． Study on the antioxidant status of vitiligo patients
of different age groups in Baroda． ［J]． Pigment cell re search sponsored by the European Society for Pigment Cell
Research and the International Pigment Cell Society，
2004，17( 3) : 289 － 294．
[5]Hazneci Ersoy，Karabulut Aysun Bay，Oztürk Cetin，Bat io
lu Kadir，Dogan Gürsoy，Karaca Semsettin，Esrefoglu Mua mmer． A comparative study of superoxide dismutase，cata lase，and glutathione peroxidase activities and nitrate lev els in vitiligo patients．［J]． International Journal of Der matology，2005，44( 8) : 636 － 640．
[6]Dammak Ines，Boudaya Sonia，Ben Mansour Riadh，El
Gaied Amel，Marrekchi Slaheddine，Turki Hamida，Attia
Hamadi，Hentati Basma． A comparative study of oxidant
– antioxidant status in stable and active vitiligo patients
［J]． Archives of Dermatological Research，2006，298
( 4) : 147 － 152．
[7]Gibbons Nicholas C J，Wood John M，Rokos Hartmut，
Schallreuter Karin U． Computer simulation of native epi dermal enzyme structures in the presence and absence of
hydrogen peroxide ( H2O2) : potential and pitfalls．［J]．
The Journal of Investigative Dermatology，2006，126( 12) :
2576 － 2582．
[8]Kalko S G，Gelpí J L，Fita I，Orozco M． Theoretical study of
the mechanisms of substrate recognition by catalase．［J]．
American Chemical Society． Journal，2001，123 ( 39 ) :
9665 － 9726．
[9]Van Remmen H，Richardson A． Oxidative damage to mito chondria and aging．［J]． Experimental Gerontology，2001，
36( 7) : 957 － 968．
[10]Jiménez － Cervantes C，Martínez － Esparza M，Pérez C，
Daum N，Solano F，García － Borrón J C． Inhibition of mel anogenesis in response to oxidative stress: transient down regulation of melanocyte differentiation markers and possi ble involvement of microphthalmia transcription factor．
［J]． Journal of Cell Science，2001，114 ( Pt 12 ) : 2335
－ 2344．
[11]刘晶，刘志军． 氧化应激与白癜风的相关性研究［J]．
中国麻风皮肤病杂志，2009，25( 9) : 679 － 681．
[12]Schallreuter K U． Successful treatment of oxidative stress
in vitiligo．［J]． Skin pharmacology and applied skin phys iology，1999，12( 3) : 132 － 138
[13]Tsiskarishvili N． ［Cuprum sulfate and vitix in the treat ment of vitiligo in children]． ［J]． Georgian Medical
News，2005，( 121) : 48 － 51．
[14]高 如 宏． 回 医 诊 断 学［M]． 银 川: 阳 光 出 版 社，
2014: 186．
[15]高如宏． 回回药方梳理［M]． 银川: 阳光出版社，2014，
76 － 101．
[16]李良松，刘懿，杨丽萍． 香药本草［M]． 北京: 中国医药
科技出版社，2000: 22．
[17]高永举，王炎杰，杨杏，等． 回药青白散痰搽剂安全性
研究［J]． 天津中医药，2013，30( 1) : 50 － 53．
[19]丁雪玲，鄢勇勇，雷鸣，等． 回药青白散痰搽剂乙醇提
取物对黑素细胞及酪氨酸酶的激活作用［J]． 中医药
临床杂志，2016，28( 4) : 562 － 564．
[20]徐静，何佳丽，杨森，等． 回药“青白散痰搽剂”对白癜
风模型豚鼠酪氨酸酶活性及黑素细胞的影响［J]． 时
珍国医国药，2016，27( 12) : 2870 － 2871．
Memo
收稿日期: 2017 － 11 － 04 编辑: 文颖娟