[1]Leasher JL,Bourne RRA,Flaxman SR,et al.Global estimates on the number of people blind or visually impaired by diabetic retinopathy:a meta-analysis from 1990 to 2010[J].Diabetes Care,2016,39(9):1643-1649.
[2]Barmas-Alamdari D,DSouza HS,Kapoor KG,et al.Intravitreal ziv-aflibercept:a comprehensive review[J].Seminars in Ophthalmology,2019,34(6):420-435.
[3]Giuliari GP,Guel DA,Gonzalez VH.Pegaptanib sodium for the treatment of proliferative diabetic retinopathy and diabetic macular edema[J].Current Diabetes Reviews,2009,5(1):33-38.
[4]Stahl A,Lepore D,Fielder A,et al.Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW):an open-label randomised controlled trial[J].Lancet,2019,394(10208):1551-1559.
[5]Network DRCR,Elman MJ,Aiello LP,et al.Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema[J].Ophthalmology,2010,117(6):1064-1077.e35.
[6]Arvindekar A,More T,Payghan PV,et al.Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi[J].Food & Function,2015,6(8):2693-2700.
[7]Jung HA,Ali MY,Choi JS.Promising inhibitory effects of anthraquinones,naphthopyrone,and naphthalene glycosides,from Cassia obtusifolia on α-glucosidase and human protein tyrosine phosphatases 1B[J].Molecules,2016,22(1):28.
[8]Lee W,Yoon G,Hwang YR,et al.Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition[J].BMB Reports,2012,45(3):141-146.
[9]Ayoub AM,Gutberlet B,Preis E,et al.Parietin cyclodextrin-inclusion complex as an effective formulation for bacterial photoinactivation[J].Pharmaceutics,2022,14(2):357.
[10]Mugas ML,Calvo G,Marioni J,et al.Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light[J].Scientific Reports,2021,11(1):23820.
[11]Liu YJ,Chu SF,Yang SW,et al.Physcion and physcion 8-O-β-glucopyranoside:a review of their pharmacology,toxicities and pharmacokinetics[J].Chemico-Biological Interactions,2019,310:108722.
[12]Shen MY,Liu YJ,Don MJ,et al.Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica[J].PLoS One,2011,6(11):e27480.
[13]Inalegwu AE,Aimola IA,Mohammed A.Physcion ameliorates pancreatic β-cell dysfunction and diabetes-related oxidative stress markers in type 2 diabetes rat model[J].Phytomedicine Plus,2021,1(4):100114.
[14]段惠惠,黄建梅,于素云,等.STZ糖尿病大鼠视网膜病变模型的再评价[J].中国比较医学杂志,2013,23(5):12-18,79.
[15]Chan LY,Takahashi M,Lim PJ,et al.Eurotium cristatum fermented okara as a potential food ingredient to combat diabetes[J].Scientific Reports,2019,9:17536.
[16]Boss JD,Singh PK,Pandya HK,et al.Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy[J].Investigative Ophthalmology & Visual Science,2017,58(12):5594-5603.
[17]Abcouwer SF.Müller cell-microglia cross talk drives neuroinflammation in diabetic retinopathy[J].Diabetes,2017,66(2):261-263.
[18]Cao Y,Li X,Shi P,et al.Effects of L-carnitine on high glucose-induced oxidative stress in retinal ganglion cells[J].Pharmacology,2014,94(3/4):123-130.
[19]Vakifahmetoglu-Norberg H,Ouchida AT,Norberg E.The role of mitochondria in metabolism and cell death[J].Biochemical and Biophysical Research Communications,2017,482(3):426-431.
[20]Dong XB,Wang L,Song GR,et al.Physcion protects rats against cerebral ischemia-reperfusion injury via inhibition of TLR4/NF-kB signaling pathway[J].Drug Design,Development and Therapy,2021,15:277-287.
[21]Lupo G,Motta C,Giurdanella G,et al.Role of phospholipases A2 in diabetic retinopathy:in vitro and in vivo studies[J].Biochemical Pharmacology,2013,86(11):1603-1613.
[22]Li JM,Wang JJ,Yu Q,et al.Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice:role of NADPH oxidase 4[J].Diabetes,2010,59(6):1528-1538.
[23]Marco E,Jha J,Sharma A,et al.Are reactive oxygen species still the basis for diabetic complications?[J].Clinical Science,2015,129(2):199-216.
[24]Hui QY,Karlstetter M,Xu ZH,et al.Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury[J].Free Radical Biology & Medicine,2020,146:181-188.
[25]Sharma A,Rizky L,Stefanovic N,et al.The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction[J].Cardiovascular Diabetology,2017,16(1):33.
[26]Tan SM,Sharma A,Stefanovic N,et al.Derivative of bardoxolone methyl,dh404,in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease[J].Diabetes,2014,63(9):3091-3103.
[27]Wang YH,Liu YP,Zhu JQ,et al.Physcion prevents high-fat diet-induced endothelial dysfunction by inhibiting oxidative stress and endoplasmic reticulum stress pathways[J].European Journal of Pharmacology,2023,943:175554.
[28]Moon PD,Han NR,Lee JS,et al.Use of physcion to improve atopic dermatitis-like skin lesions through blocking of thymic stromal lymphopoietin[J].Molecules,2019,24(8):1484.
基金项目:陕西省优秀中医药人才研修项目(陕中医药函【2022】102号);陕西省重点研发计划(2017SF-350);咸阳市科学技术研究计划项目(2015k04-17)