[1]赵艳莉 李仁廷 吴召利.扶正祛痰方联合顺铂治疗非小细胞肺癌的实验研究[J].现代中医药,2018,(04):102-105.[doi:10.13424/j.cnki.mtcm.2018.04.033]
Zhao Yanli Li Renyan Wu Zhaoli.Experimental Study on the Treatment of Non - small Cell Lung
Cancer with Fuzheng Qutan Recipe Combined with Cisplatin[J].Modern Traditional Chinese Medicine,2018,(04):102-105.[doi:10.13424/j.cnki.mtcm.2018.04.033]
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扶正祛痰方联合顺铂治疗非小细胞肺癌的实验研究()
《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
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- 期数:
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2018年04期
- 页码:
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102-105
- 栏目:
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药物研究
- 出版日期:
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2018-07-10
文章信息/Info
- Title:
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Experimental Study on the Treatment of Non - small Cell Lung
Cancer with Fuzheng Qutan Recipe Combined with Cisplatin
- 文章编号:
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1672-0571(2018)04-0102-04
- 作者:
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赵艳莉 李仁廷 吴召利
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陕西中医药大学附属医院,陕西 咸阳 712000
- Author(s):
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Zhao Yanli Li Renyan Wu Zhaoli
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The First Tumor Division of the Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang China,712000
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- 关键词:
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扶正祛痰方; 顺铂; 非小细胞肺癌; 联合治疗
- Keywords:
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Fuzheng Qutan Recipe; cisplatin; non - small cell lung cancer; combined therapy
- 分类号:
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R734
- DOI:
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10.13424/j.cnki.mtcm.2018.04.033
- 文献标志码:
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A
- 摘要:
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目的 探究扶正祛痰方联合顺铂治疗非小细胞肺癌的有效性及作用机制。方法 以“扶正祛痰方”
为实验用药,以 40 只 LL/2 荷瘤 C57BL/6J 小鼠为对象,分为对照组、顺铂组、中药组及中西医结合组,每组 10
只,分别于第 3 天、第 7 天、第 14 天、第 21 天测肿瘤体积,第 21 天后处死,取出脾脏、胸腺及肿瘤组织称重,对肿
瘤组织行免疫组化法检测肿瘤细胞数。结果 抑瘤率: 中西医结合组 > 顺铂组 > 中药组 > 对照组; 扶正祛痰方组
和联合组肺癌小鼠的脾脏指数和胸腺指数较顺铂组高,且差
- Abstract:
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Objective: To explore the efficacy and mechanism of Fuzheng Qutan Recipe combined with
cisplatin in the treatment of non - small cell lung cancer. Method: Taking Fuzheng Qutan Recipe as a
tool,40 LL /2 tumor - bearing C57BL /6J mice were divided into control group,cisplatin group,tradi tional Chinese medicine group and integrated traditional Chinese and western medicine group,with 10
in each group. The tumor volume was measured on the 3rd,7th,14th and 21st day. After the 21st
day,the tumor was sacrificed. The spleen,thymus,and tumor tissues were weighed. The tumor tissue
was examined by immunohistochemistry to determine the number of tumor cells. Result: Tumor inhibition
rate: integrated traditional Chinese and Western medicine group > cisplatin group > Chinese medicine
group > control group; the spleen index and thymus index of the mice with lung cancer in Fuzheng Qu tan Recipe group and the combined group were higher than that of the cisplatin group,and the differ ence was statistically significant ( P < 0. 05) . Conclusion: Fuzheng Qutan Recipe can improve the immu nity of the body,has a certain anti tumor effect,and can relieve the side effect of cisplatin to the body.The combined use of Fuzheng Qutan Recipe and cisplatin can obviously improve the survival rate and
the quality of life.
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备注/Memo
- 备注/Memo:
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收稿日期: 2016 - 09 - 21 编辑: 文颖娟
更新日期/Last Update:
2019-12-09