[1]蒋 苏 鲁 峻 赵高年 金 景 降建新.针刺结合尼莫地平对急性脑梗死患者的疗效及炎症反应的影响[J].现代中医药,2020,(04):050-55.[doi:10.13424/j.cnki.mtcm.2020.04.012]
　Jiang Su,Lu Jun,Zhao Gaonian,et al.The Influence on the Patients′Curative Effect and Inflammatory Response in the Treatment of Acute Cerebral Infarction by Acupuncture and Nimodipine[J].Modern Traditional Chinese Medicine,2020,(04):050-55.[doi:10.13424/j.cnki.mtcm.2020.04.012]
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针刺结合尼莫地平对急性脑梗死患者的疗效及炎症反应的影响()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年04期
页码:
050-55
栏目:
出版日期:
2020-07-10

文章信息/Info

Title:
The Influence on the Patients′Curative Effect and Inflammatory Response in the Treatment of Acute Cerebral Infarction by Acupuncture and Nimodipine
文章编号:
1672-0571(2020)04-0050-06
作者:
蒋 苏1 鲁 峻2 赵高年1 金 景1 降建新2
1.泰州市人民医院康复医学科,江苏泰州225300;
2.泰州市人民医院神经外科,江苏泰州225300
Author(s):
Jiang Su 1 ;  Lu Jun 2 ;  Zhao Gaonian 1 ;  Jin Jing 1 ;  Jiang Jianxin 2
1. Rehabilitation Department of Taizhou People’ s Hospital, Taizhou Jiangsu 2253002；
2. Neurosurgery Department of Taizhou People’ s Hospital, Taizhou Jiangsu 2253002；
关键词:
急性脑梗死; 针刺; 尼莫地平; 脑血流动力学; 神经损伤
Keywords:
Acute Cerebral Infarction;  acupuncture;  Nimodipine;  hemodynamics;  nerve injury
分类号:
R245.31
DOI:
10.13424/j.cnki.mtcm.2020.04.012
文献标志码:
A
摘要:
目的探讨针刺结合尼莫地平治疗急性脑梗死的疗效?方法选取2015年9月~2017年11月间在本院接受治疗的急性脑梗死患者80例作为研究对象,将其分为接受常规治疗+尼莫地平治疗的对照组43例?接受常规治疗+尼莫地平+针刺治疗的针刺组37例?对比两组患者治疗前?治疗后4周脑血流动力学指标水平及血清中脑损伤指标?炎症反应相关指标含量的差异;对比两组患者治疗前后中医证侯评分?结果治疗后4周,针刺组的Vm水平高于对照组,PI?RI水平低于对照组(P<0.05)?开始治疗后4周,针刺组血清中GFAP?MBP?NSE的含量低于对照组(P<0.05)?开始治疗后4周,针刺组中医证侯评分及梗死部位直径均低于对照组(P<0.05)?开始治疗后4周,针刺组血清中TGF-β1?ICAM-1?IL-8?TNF-α的含量低于对照组(P<0.05)?结论急性脑梗死患者在尼莫地平治疗同时加入针刺进行辅助治疗,可有效优化患者脑血流状态并减轻神经损伤,抑制患者炎症反应?
Abstract:
Objective To explore the curative effect of the treatment of Acute Cerebral Infarction by acupuncture and nimodipine. Method To select 80 hospitalized patients suffering from the acute cerebral infarction ranging from September in 2015 to November in 2017 as the objects. They are randomely divided into the regular treatment group plus Nimodipine with 43cases and the regular treatment plus Nimodipine and acupuncture group with 37 cases. The variations in the hemodynamic index and the index of brain injury in the serum as well as the inflammatory response index before and after 4 weeks treatment are compared while the TCM syndrome scores between the two groups are compared. Result After 4 weeks treatment, the VM in the acupuncture group is lower than the control group( p <0. 05) , while the GFAP, MBP andNSE in the serum of the acuuncture group is lower than the control group( p <0. 05) . After 4 weeks, the GF - β1? ICAM-1? IL -8? TNF - αin the serum of the acupuncture group is lower than the control group( p <0. 05) . Conclusion Patients with acute cerebral infarction can be treated by Nimodpine plus the acupuncture, thus optimizing the patients’ cerebral blood flow and alleviate the nerve injury to supress the inflammaroty response.

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备注/Memo

备注/Memo:
基金项目:泰州市科技项目(TS201804)
通讯作者:降建新,博士,主治医师?E-mial:mao_991918@163.com
更新日期/Last Update: 2020-07-15