[1]田永仓 赵丹 柏本健 康小琴 聂太宝 韦庄怡 王敏.当归补血方对冠状动脉搭桥术后 心功能及血清IL-6、NT-proBNP的影响[J].现代中医药,2022,1(01):127-132.[doi:10.13424/j.cnki.mtcm.2022.01.026]
　TIAN Yongcang ZHAO Dan BAI Benjian KANG Xiaoqin NIE Taibao WEI Zhuangyi WANG Min.Effects of Danggui Buxue Recipe on Cardiac Function and Serum IL-6 and NT-proBNP After Coronary Artery Bypass Grafting[J].Modern Traditional Chinese Medicine,2022,1(01):127-132.[doi:10.13424/j.cnki.mtcm.2022.01.026]
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当归补血方对冠状动脉搭桥术后 心功能及血清IL-6、NT-proBNP的影响
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年01期
页码:
127-132
栏目:
临床精粹
出版日期:
2022-01-20

文章信息/Info

Title:
Effects of Danggui Buxue Recipe on Cardiac Function and Serum IL-6 and NT-proBNP After Coronary Artery Bypass Grafting
文章编号:
1672-0571(2022)01-0127-06
作者:
田永仓1 赵丹1 柏本健1 康小琴1 聂太宝1 韦庄怡1 王敏2
1.陕西中医药大学第二附属医院心胸外科，陕西 西咸新区 712000；
2.陕西中医药大学第二附属医院心内科，陕西 咸阳 712000
Author(s):
TIAN Yongcang1 ZHAO Dan1 BAI Benjian1 KANG Xiaoqin1 NIE Taibao1 WEI Zhuangyi1 WANG Min2
1. Department of Cardiothoracic Surgery, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi Xi'an new area 712000,China;
2. Department of Cardiology, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi xianyang 712000,China
关键词:
关键词：冠状动脉搭桥术; 冠心病; 心功能; 白介素-6; N末端脑钠肽前体
Keywords:
Key words：Coronary artery bypass grafting;  Coronary heart disease;  Cardiac function;  Interleukin-6;  N-terminal pro brain natriuretic peptide
分类号:
R246.1
DOI:
10.13424/j.cnki.mtcm.2022.01.026
文献标志码:
A
摘要:
摘 要：目的 分析当归补血方对冠状动脉搭桥术后心功能及血清白介素（IL-6）、N末端脑钠肽前体（NT-proBNP）的影响。方法 选取 2017年2月—2019年2月期间在陕西中医药大学第二附属医院心胸外科行冠状动脉搭桥术的冠心病患者50例，按照随机数字表法分为对照组和治疗组，每组25例。对照组患者术后接受常规治疗，治疗组在对照组治疗的基础上加服当归补血汤治疗。治疗6个月后比较两组临床疗效、中医证候积分、心功能、IL-6、NT-proBNP、TNF-α及不良反应。结果 治疗后治疗组中医症候积分较对照组低（10.25±5.91 vs 1630±6.25），差异有统计学意义（P<0.05）。治疗组临床总有效率较对照组高（96.00% vs 76.00%），差异有统计学意义（P<0.05）。治疗后治疗组患者左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）均低于对照组（53.13±5.24、46.15±4.32 vs 56.28±5.64、46.15±4.32），而左室射血分数（LVEF）高于对照组（54.75±9.45 vs 48.56±9.05），差异有统计学意义（P<0.05）。治疗后治疗组患者血清IL-6、NT-proBNP、肿瘤坏死因子-α均低于对照组（132.56±34.45、719.42±103.56、10.24±2.89 vs 163.89±50.13、954.87±116.88、16.35±3.56），差异有统计学意义（P<0.05）。两组患者均未出现明显不良反应，肝功能检测正常。结论 当归补血方用于冠状动脉搭桥术后患者的治疗可明显改善患者的心功能，降低炎症反应，安全性较高，临床治疗效果显著。
Abstract:
Abstract：Objective To analyze the effects of Danggui Buxue recipe on cardiac function, serum interleukin-6 (IL-6) and N-terminal pro brain natriuretic peptide(NT-proBNP) after coronary artery bypass grafting. Methods 50 patients with coronary heart disease who underwent coronary artery bypass grafting in the cardiothoracic surgery of the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine from February 2017 to February 2019 were randomly divided into control group and observation group, with 25 cases in each group. The patients in the control group received routine treatment after operation, and the observation group took Danggui Buxue decoction on the basis of the treatment of the control group Therapy. After 6 months of treatment, the clinical efficacy, TCM syndrome score, cardiac function, IL-6, NT proBNP and TNF-α and adverse reactions were compared. Results After treatment, the TCM symptom score in the observation group was lower than that in the control group (10.25±5.91 vs 16.30±6.25), and the difference was statistically significant (P<0.05). The total clinical effective rate in the observation group was higher than that in the control group (96.00% vs 76.00%), and the difference was statistically significant (P<0.05). After treatment, the left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter in the observation group were significantly higher (LVESD) was lower than that in the control group (53.13±5.24,46.15±4.32 vs 56.28±5.64,46.15±4.32), while the left ventricular ejection fraction (LVEF) was higher than that in the control group (54.75±9.45 vs 48.56±9.05), the difference was statistically significant (P<0.05).After treatment, serum IL-6, NT-proBNP and tumor necrosis factor-α were lower than the control group（132.56±34.45，719.42±103.56，10.24±2.89 vs 163.89±50.13，954.87±116.88，1635±3.56）(P<0.05). There were no obvious adverse reactions in both groups, and the liver function test was normal. Conclusion Danggui Buxue recipe can significantly improve the cardiac function and reduce the inflammatory reaction of patients after coronary artery bypass grafting, with high safety and significant clinical therapeutic effect.

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备注/Memo

备注/Memo:
基金项目：陕西省中医药管理局科研项目(LCPT075）
更新日期/Last Update: 2022-02-18