[1]尹丽黄菊云卢成淑蒋德旗曾诗媛王华坤.多组学整合策略在中药抗抑郁机制研究中的应用[J].现代中医药,2024,(02):001-7.[doi:10.13424/j.cnki.mtcm.2024.02.001]
　YIN LiHUANG JuyunLU ChengshuJIANG Deqi?ZENG ShiyuanWANG Huakun.Application of Multi Omics Integration Strategy in Study of Antidepressant Mechanisms in Traditional Chinese Medicine[J].Modern Traditional Chinese Medicine,2024,(02):001-7.[doi:10.13424/j.cnki.mtcm.2024.02.001]
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多组学整合策略在中药抗抑郁机制研究中的应用()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年02期
页码:
001-7
栏目:
出版日期:
2024-03-20

文章信息/Info

Title:
Application of Multi Omics Integration Strategy in Study of Antidepressant Mechanisms in Traditional Chinese Medicine
文章编号:
1672-0571(2024)02-0001-07
作者:
尹丽1; 2黄菊云1卢成淑1蒋德旗1; 2曾诗媛1王华坤1
1.玉林师范学院，广西 玉林 537000；
2.玉林师范学院地产药用资源开发与生物工程技术中心，广西 玉林 537000
Author(s):
YIN Li1; 2HUANG Juyun1LU Chengshu1JIANG Deqi1; 2?ZENG Shiyuan1WANG Huakun1
1.Yulin Normal University，Guangxi Yulin 537000,China；
2.Yulin Normal UniversityReal Estate Medicinal Resource Development and Biotechnology Center,Guangxi Yulin 537000,China
关键词:
关键词：多组学; 作用机制; 中药; 抗抑郁; 整合技术
Keywords:
Key words:Multi omics; Mechanism of action; Traditional Chinese medicine; Anti depression; Integration technology
分类号:
R277.7
DOI:
10.13424/j.cnki.mtcm.2024.02.001
文献标志码:
A
摘要:
摘要：抑郁症是一种常见的精神和心理疾病，发病机制复杂，中医辨证论治治疗抑郁症具有因人而异、因病而异的独特优势。随着分子生物学技术快速发展，多组学技术在中药有效成分抗抑郁效果的分析中得到广泛应用。文章系统介绍了多组学的核心技术，重点综述了近年来基因组学、蛋白质组学、转录组学、代谢组学和多组学整合技术在中药抗抑郁作用机制研究中的思路、方法和进展，为推进多组学技术在中药治疗抑郁症中的应用提供参考。
Abstract:
Abstract：Depression is a common mental and psychological disorder with a complex pathogenesis.Traditional Chinese medicine has unique advantages in treating depression based on syndrome differentiation and treatment，which vary from person to person and from disease to disease.With the rapid development of molecular biology technology，multi omics techniques have been widely applied in the analysis of the antidepressant effects of effective ingredients in traditional Chinese medicine.The article systematically introduces the core technologies of multi omics，with a focus on summarizing the ideas，methods，and progress of genomics，proteomics，transcriptomics，metabolomics，and multi omics integration technologies in the study of the mechanism of antidepressant effects of traditional Chinese medicine in recent years，providing reference for promoting the application of multi omics technologies in the treatment of depression with traditional Chinese medicine.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目(81960658)；广西高校中青年教师科研基础能力提升项目(2021KY0584)；玉林师范学院高层次人才科研启动项目(G2018027)
更新日期/Last Update: 2024-03-26