[1]汤融庞芙蓉赵娇罗可严庆汪鸽李翡**.中药单体调控Wnt/β-catenin信号通路干预卵巢癌研究进展[J].现代中医药,2024,(04):007-12.[doi:10.13424/j.cnki.mtcm.2024.04.002]
　TANG RongPANG FurongZHAO JiaoLUO KeYAN QingWANG GeLI Fei.Research Progress on the Intervention of Ovarian Cancer byRegulating the Wnt/β-catenin Signaling Pathwaywith Traditional Chinese Medicine Monomers[J].Modern Traditional Chinese Medicine,2024,(04):007-12.[doi:10.13424/j.cnki.mtcm.2024.04.002]
点击复制

中药单体调控Wnt/β-catenin信号通路干预卵巢癌研究进展()
分享到：

《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年04期
页码:
007-12
栏目:
出版日期:
2024-08-28

文章信息/Info

Title:
Research Progress on the Intervention of Ovarian Cancer byRegulating the Wnt/β-catenin Signaling Pathwaywith Traditional Chinese Medicine Monomers
文章编号:
1672-0571(2024)04-0007-06
作者:
汤融1庞芙蓉1赵娇1罗可1严庆1汪鸽2李翡2**
1.陕西中医药大学，陕西 咸阳 712046；
2.陕西中医药大学附属医院，陕西 咸阳 712000
Author(s):
TANG Rong1PANG Furong1ZHAO Jiao1LUO Ke1YAN Qing1WANG Ge2LI Fei1
1.Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;
2.Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712000,China
关键词:
关键词：中药单体; 卵巢癌; Wnt/β-catenin信号通路; 抗肿瘤; 研究进展
Keywords:
Key words:Traditional Chinese medicine monomers; Ovarian cancer; Wnt/β-catenin signaling pathway; Anti-tumor; Research progress
分类号:
R271
DOI:
10.13424/j.cnki.mtcm.2024.04.002
文献标志码:
A
摘要:
摘 要：卵巢癌是女性三大恶性肿瘤之一，严重危害女性生命健康。卵巢癌发生发展过程中，众多信号通路发挥着至关重要的作用，其中Wnt/β-catenin信号通路是主要调控通路之一。近年来，中医药抗肿瘤的优势逐渐显现，研究发现，五味子乙素、 淫羊藿苷、白藜芦醇和丹皮酚等多种中药单体可以通过调控Wnt/β-catenin信号通路发挥抑制卵巢癌细胞生长增殖、阻滞细胞周期、增加铂化疗敏感性等作用。基于国内外研究现状，通过整理归纳中药单体通过调控Wnt/β-catenin信号通路干预卵巢癌的研究进展，力求为中医药治疗卵巢癌提供参考，同时也为新药研发开拓思路。
Abstract:
Abstract：Ovarian cancer is one of the three major malignant tumors in women, which seriously endangers women’s life and health. During the occurrence and development of ovarian cancer, numerous signaling pathways play a crucial role, among which the Wnt/β-catenin signaling pathway is one of the main regulatory pathways. In recent years, the advantages of traditional Chinese medicine in anti-tumor treatment have gradually emerged. Research has found that various traditional Chinese medicine monomers such as Schisandrin B, icariin, resveratrol, and paeonol can inhibit the growth and proliferation of ovarian cancer cells, block the cell cycle, and increase platinum chemotherapy sensitivity by regulating the Wnt/β-catenin signaling pathway. Based on the current research status at home and abroad, this paper summarizes the research progress of traditional Chinese medicine monomers intervening in ovarian cancer by regulating the Wnt/β-catenin signaling pathway, aiming to provide reference for the treatment of ovarian cancer with traditional Chinese medicine and also explore new ideas for drug development.

参考文献/References:

［1］FERLAY J,COLOMBET M,SOERJOMATARAM I,et al.Cancer statistics for the year 2020:an overview［J］.International Journal of Cancer,2021,149(4):778-789.
［2］GREENLEE RT,MURRAY T,BOLDEN S,et al.Cancer statistics,2000.［J］.Ca A Cancer Journal for Clinicians,2010,50(1):7-33.
［3］韩喜婷,孙长青,程亮星,等.1990—2019年中国卵巢癌疾病负担及其变化趋势分析［J］.中国肿瘤,2023,32(5):333-338.
［4］汤梓莹,邓明港,宇传华,等.中国卵巢癌疾病负担现状及趋势分析［J］.国际妇产科学杂志,2022,49(2):222-227.
［5］文敏,周欣,赵超,等.中药抗卵巢癌作用及机制研究新进展［J］.天然产物研究与开发,2021,33(3):521-533.
［6］ZHANG G,MICHENER CM,YANG B.Low-grade ovarian stromal tumors with genetic alterations of the Wnt/β-catenin pathway that is crucial in ovarian follicle development and regulation［J］.Cancers,2022,14(22):5622.
［7］TOSSETTA G,MARZIONI D.Natural and synthetic compounds in Ovarian Cancer:a focus on NRF2/KEAP1 pathway［J］.Pharmacological Research,2022,183:106365.
［8］ARISAN ED,RENCUZOGULLARI O,COBAN M,et al.The role of the PI3K/AKT/mTOR signaling axis in the decision of the celastrol-induced cell death mechanism related to the lipid regulatory pathway in prostate cancer cells［J］.Phytochemistry Letters,2020,39:73-83.
［9］YU L,WEI J,LIU PD.Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer［J］.Seminars in Cancer Biology,2022,85:69-94.
［10］李雪雪,卫旭东,王倩茹.USP22调控肿瘤中信号转导通路的研究进展［J］.中国细胞生物学学报,2024,46(2):345-354.
［11］NUSSE R,CLEVERS H.Wnt/β-catenin signaling,disease,and emerging therapeutic modalities［J］.Cell,2017,169(6):985-999.
［12］万小亚,杨泽,李阳,等.Wnt信号通路与恶性肿瘤的研究进展［J］.中国医药导报,2016,13(36):71-73,77.
［13］李康华,李星星,吴凡,等.Wnt/β-catenin通路在肿瘤免疫和免疫治疗中的研究进展［J］.生命科学,2022,34(11):1386-1393.
［14］CAVALLO RA,COX RT,MOLINE MM,et al.Drosophila Tcf and Groucho interact to repress Wingless signalling activity［J］.Nature,1998,395(6702):604-608.
［15］Arce L,Pate KT,Waterman ML.Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression［J］.BMC Cancer,2009,9:159.
［16］CHOCARRO-CALVO A,GARCA-MARTNEZ JM,ARDILA-GONZLEZ S,et al.Glucose-induced β-catenin acetylation enhances Wnt signaling in cancer［J］.Molecular Cell,2013,49(3):474-486.
［17］BILIC J,HUANG YL,DAVIDSON G,et al.Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation［J］.Science,2007,316(5831):1619-1622.
［18］ZHANG Y,WANG X.Targeting the Wnt/β-catenin signaling pathway in cancer［J］.Journal of Hematology & Oncology,2020,13(1):165.
［19］RICKEN A,LOCHHEAD P,KONTOGIANNEA M,et al.Wnt signaling in the ovary:identification and compartmentalized expression of wnt-2,wnt-2b,and frizzled-4 mRNAs［J］.Endocrinology,2002,143(7):2741-2749.
［20］裴越.Wnt通路在卵巢癌发生发展中的作用研究［D］.长春:吉林大学,2021.
［21］TEEUWSSEN M,FODDE R.Wnt signaling in ovarian cancer stemness,EMT,and therapy resistance［J］.Journal of Clinical Medicine,2019,8(10):1658.
［22］张展,朱海,宋华,等.Lgr5、β-catenin在卵巢上皮性癌组织中的表达及对SKOV3细胞增殖迁移的影响［J］.郑州大学学报(医学版),2017,52(2):138-142.
［23］姚彬,张庆华.Wnt/β-catenin信号通路在卵巢癌干细胞增殖、迁移和侵袭中的作用［J］.中国组织工程研究,2018,22(25):4001-4006.
［24］冯姗姗,郑洪,王凯.沉默LOXL2表达对卵巢癌SKOV3细胞生长及Wnt/β-catenin信号通路的影响［J］.郑州大学学报(医学版),2020,55(1):41-44.
［25］徐林,张巧丽,姜欣,等.黄金昶治疗卵巢癌的辨证思路及用药经验［J］.北京中医药,2018,37(12):1149-1151.
［26］陈思思,李平,邵翠丽,等.从湿论治卵巢癌［J］.吉林中医药,2021,41(6):741-743.
［27］徐国暑,谢鑫灵,陈嘉斌,等.柴可群从肝论治卵巢癌经验总结［J］.中医肿瘤学杂志,2021,3(1):38-42.
［28］吴晓晴,常磊,卢雯平.益气活血解毒方调控IL-6对铂耐药卵巢癌患者巨噬细胞表型的影响［J］.北京中医药大学学报,2022,45(2):208-216.
［29］田璐,张新,张阳.扶正抗癌汤免疫调节及抑制大鼠卵巢癌移植瘤生长的作用［J］.中国实验方剂学杂志,2021,27(10):38-43.
［30］郭秀霞.补气活血药配伍对卵巢癌原位移植瘤作用分子机制研究［D］.南京:南京中医药大学,2016.
［31］时晓霞,唐德才,尹刚,等.黄芪、莪术配伍对人卵巢癌HO-8910原位移植瘤组织中MMP-2、FGF-2、BCL-2表达的影响［J］.中华中医药学刊,2018,36(6):1312-1315.
［32］唐德才,臧文华,冯海红.莪术不同品种含药血清抑制人卵巢癌细胞HO-8910增殖及诱导凋亡的实验研究［J］.时珍国医国药,2013,24(10):2313-2315.
［33］谷少华,刘巧方,李向南.白芷提取物通过调控SBF2-AS1/miR-329-3p轴影响卵巢癌细胞增殖及凋亡［J］.中国老年学杂志,2021,41(23):5360-5365.
［34］郑玲,刘杏,刘雨,等.药用植物珍珠菜提取物ZE4调控卵巢癌细胞增殖、侵袭和迁移的分子机制［J］.分子植物育种,2022,20(6):2043-2049.
［35］LI SP,WANG H,MA RD,et al.Schisandrin B inhibits epithelial-mesenchymal transition and stemness of large-cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF-κB and p38 MAPK signaling pathways［J］.Oncology Reports,2021,45(6):115.
［36］WANG YP,CHEN J,HUANG YR,et al.SchisandrinB suppresses osteosarcoma lung metastasis invivo by inhibiting the activation of the Wnt/β-catenin and PI3K/Akt signaling pathways［J］.Oncology Reports,2022,47(3):50.
［37］沈华杰,万宗明.五味子乙素抗肿瘤作用研究进展［J］.中成药,2020,42(7):1847-1850.
［38］曾雯琼,徐青,许银燕.五味子乙素对人卵巢癌Skov3细胞株的增殖、凋亡及Wnt/β-catenin信号通路的影响［J］.临床肿瘤学杂志,2014,19(7):589-593.
［39］YANG C,JIN YY,MEI J,et al.Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis［J］.Cancer Cell International,2022,22(1):202.
［40］李秋瑞,侯科名,王猛,等.淫羊藿素对人卵巢癌A2780细胞增殖、凋亡、迁移和侵袭的影响［J］.中国实验方剂学杂志,2021,27(20):101-107.
［41］陈茹,苏莹,柳江.淫羊藿苷通过Wnt/β-catenin信号通路对卵巢癌细胞CAOV3增殖的影响［J］.医学研究杂志,2019,48(3):44-49.
［42］FU YJ,LIU HQ,LONG MS,et al.Icariin attenuates the tumor growth by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling axis in ovarian cancer［J］.Frontiers in Oncology,2022,12:940926.
［43］孔涛,马彦博,杨自军,等.白藜芦醇的生物学功能及作用机制［J］.中国临床药理学杂志,2022,38(6):592-596.
［44］王真,陈立伟.白藜芦醇抗肿瘤药理作用机制研究进展［J］.药物评价研究,2023,46(2):445-451.
［45］王丽娟,史惠蓉.白藜芦醇通过调控SIRT1抑制卵巢癌细胞生长及Wnt信号通路的研究［J］.中草药,2019,50(3):675-680.
［46］侯政瑶,高杰,吴雨,等.白藜芦醇对卵巢癌细胞增殖活力、增殖基因mRNA表达及Wnt信号通路的影响［J］.中国肿瘤外科杂志,2020,12(1):63-66.
［47］杨山景,李凌军.丹皮酚药理作用与应用研究进展［J］.中药药理与临床,2022,38(5):237-241.
［48］尚雯倩,张艾民,华玉双,等.丹皮酚抗肿瘤作用机制的研究进展［J］.现代药物与临床,2019,34(9):2864-2869.
［49］李倩男,王琳琳,汤剑明,等.丹皮酚通过调控Wnt/β-catenin信号通路抑制人卵巢癌A2780细胞增殖的实验研究［J］.中华实用诊断与治疗杂志,2017,31(11):1062-1066.
［50］崔明花,付二花,林贞花,等.姜黄素抗肿瘤药理作用的研究进展［J］.中国临床药理学杂志,2021,37(2):186-188,196.
［51］YEN HY,TSAO CW,LIN YW,et al.Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line［J］.Scientific Reports,2019,9(1):17267.
［52］胡锦丹,王宇.苦参碱抗肿瘤作用机制的研究进展［J］.中华中医药学刊,2022,40(5):171-175.
［53］王亚萍.苦参碱对卵巢癌大鼠的干预效果及对Wnt/β-catenin通路的影响［J］.中国妇幼保健,2022,37(8):1495-1499.
［54］尚雯倩,张艾民,付燕,等.粉防己碱抗肿瘤作用机制的研究进展［J］.现代中西医结合杂志,2021,30(3):324-328,338.
［55］王永玲,贾秀改,朱洁,等.粉防己碱调控miR-21表达抑制卵巢癌上皮间质转化的实验研究［J］.上海中医药杂志,2020,54(8):71-76.
［56］DUAN JX,YIN MY,SHAO YQ,et al.Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1［J］.The Journal of International Medical Research,2021,49(9):3000605211040762.
［57］WANG YM,REN N,RANKIN GO,et al.Anti-proliferative effect and cell cycle arrest induced by saponins extracted from tea (Camellia sinensis) flower in human ovarian cancer cells［J］.Journal of Functional Foods,2017,37:310-321.
［58］陈莲芙,任苧,陈益,等.茶树花皂苷对卵巢癌干细胞样细胞增殖的影响及机制［J］.浙江大学学报(农业与生命科学版),2020,46(6):667-676.
［59］陈莲芙.茶树花皂苷对人卵巢癌细胞及其干细胞的抑制与机理［D］.杭州:浙江大学,2020.
［60］KOIKE T,TAKENAKA M,SUZUKI N,et al.Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells［J］.Journal of Clinical Biochemistry and Nutrition,2022,71(1):34-40.
［61］丁娜,贺红林,袁怡君,等.青蒿琥酯通过调节卵巢癌细胞中Wnt/β-catenin信号通路诱导铁死亡［J］.现代妇产科进展,2023,32(7):504-509.
［62］刘明浦,廖年生,李海荣,等.野漆树苷的生物活性研究进展［J］.中国医药指南,2023,21(36):62-65.
［63］张建忠,马端兰,张世红,等.芹菜素调控Wnt信号通路对卵巢癌细胞侵袭能力的影响［J］.肿瘤药学,2017,7(3):284-289.
［64］邵香敏,李珂,冯爽,等.槲皮素的生物学功能及其在动物生产中应用研究进展［J］.饲料工业,2023,44(17):29-35.
［65］李阳杰,曹瑞梅,毛雅君,等.槲皮素的结构修饰及生物活性研究进展［J］.中草药,2023,54(5):1636-1653.
［66］赵艳,郑彩霞,万秋园,等.槲皮素与FSCN1基因siRNA联合对卵巢癌生长抑制及免疫功能的影响研究［J］.临床和实验医学杂志,2018,17(18):1947-1951.
［67］徐芳娣.去氢骆驼蓬碱通过Wnt/β-catenin信号通路对卵巢癌细胞凋亡、侵袭的影响［D］.赣州:赣南医学院,2022.
［68］龚建明,周莹巧,林琪.羟基红花黄色素A通过Wnt/β-catenin信号通路抑制卵巢癌生长［J］.医学研究杂志,2019,48(10):131-134.
［69］吴金兰,万慧芳,梁笑倾,等.大蒜素通过调控GSK-3β/β-Catenin通路抑制卵巢癌细胞侵袭转移的研究［J］.实用癌症杂志,2023,38(4):523-528.
［70］贾晓晴,佟晓哲.巴西苏木素通过激活Wnt/β-catenin通路调控卵巢癌SKOV3细胞增殖、凋亡、迁移和侵袭的研究［J］.中国临床药理学杂志,2023,39(9):1237-1241.
［71］龙昌志.喙尾琵琶甲乙酸乙酯提取物抑制卵巢癌细胞增殖及血管生成［D］.大理:大理大学,2023.
［72］王泯蓉,张勇,沈娟.山慈菇多糖对人卵巢癌细胞增殖和上皮间质转化的影响［J］.中国临床药理学杂志,2023,39(13):1899-1903.
［73］宋健,袁敏惠,崔冰慧,等.金果胃康胶囊对PLGC大鼠Wnt/Lgr5信号通路的干预研究［J］.陕西中医药大学学报,2022,45(5):102-108.

相似文献/References:

[1]陈丽 郑玉玲.郑玉玲教授治疗卵巢癌用药规律分析[J].现代中医药,2022,1(06):073.[doi:10.13424/j.cnki.mtcm.2022.06.015]
　CHEN Li ZHENG Yuling.Analysis of Professor ZHENG Yuling’s Medication Rule for Ovarian Cancer[J].Modern Traditional Chinese Medicine,2022,1(04):073.[doi:10.13424/j.cnki.mtcm.2022.06.015]

备注/Memo

备注/Memo:
基金项目：陕西省科技计划项目（2020SF-052）；陕西省教育厅专项科研计划项目（20JK0595）
更新日期/Last Update: 2024-07-15