[1]刘迎宣 李子楠.中药黄芪颗粒对儿童急性柯萨奇病毒感染导致病毒性心肌炎免疫调节的研究[J].现代中医药,2017,(03):017.[doi:10.13424/j.cnki.mtcm.2017.03.007]
　Liu Yingxuan Li Zinan.Treatment of Viral Myocarditis of Acute CVI Children by Huangqi Granules[J].Modern Traditional Chinese Medicine,2017,(03):017.[doi:10.13424/j.cnki.mtcm.2017.03.007]
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中药黄芪颗粒对儿童急性柯萨奇病毒感染导致病毒性心肌炎免疫调节的研究()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年03期
页码:
017
栏目:
临床研究
出版日期:
2017-05-03

文章信息/Info

Title:
Treatment of Viral Myocarditis of Acute CVI Children by Huangqi Granules
文章编号:
1672－0571(2017)03－0017－02
作者:
刘迎宣1 李子楠2
1． 陕西省结核病防治院，陕西 西安 710101; 2． 西安市远东第一中学，陕西 西安 710077
Author(s):
Liu Yingxuan1 Li Zinan2
1． Shaanxi Tuberculosis Hospital，Xi’an 710101，China; 2． Xi’an Yuandong No． 1 Middle School，Xi’an 710077，China
关键词:
儿童;  急性柯萨奇病毒感染阶段;  病毒性心肌炎;  Th1 /Th2 失衡;  IFN － γ;  IL － 4;  黄芪颗粒
Keywords:
children; acute CVI ; viral myocarditis; Th1 /Th2 imbalance; Huangqi Granules
分类号:
Ｒ37
DOI:
10.13424/j.cnki.mtcm.2017.03.007
文献标志码:
A
摘要:
目的 探讨儿童急性柯萨奇病毒感染阶段病毒性心肌炎 Th1 /Th2 失衡和中药黄芪颗粒治疗的效果。 方法 按随机抽样设儿童急性柯萨奇病毒感染阶段病毒性心肌炎治疗 1 组，治疗 2 组与正常对照组，通过检查血 清 IFN － γ、IL － 4、cTnI、cTnT 水平及 ECG，间接了解此类心肌炎 Th1 /Th2 失衡和心肌损伤状态，观察用中药黄芪 颗粒后 Th1 /Th2 平衡恢复与心肌炎治愈率得到提高的变化。结果 治疗前治疗 1、2 组 IFN － γ 水平低于对照组 ( P ＜ 0． 05) ，IL － 4 水平高于对照组( P ＜ 0． 05) ，显示 Th1 /Th2 免疫优势向 Th2 倾斜，用黄芪颗粒治疗后，治疗 2 组 IFN － γ 上调，IL － 4 下移达到对照组水平( P 均 ＞ 0． 05) ，Th1 /Th2 回到平衡，异常 ECG 消失率与 cTnI、cTnT 阴 性转换率比治疗 1 组高( P 均 ＜ 0． 01) 。结论 Th1 /Th2 失衡也是该类心肌炎的表明用中药黄芪颗粒调节有效， 心肌炎治愈率因此获得提高。
Abstract:
Objective: To investigate the effect of Huangqi Granules on viral myocarditis children of acute coxsackie virus infection ( CVI) at infected stage，in which the mechanism of Th1 /Th2 imbalance was explored． Method: The first experimental group was randomly arranged in acute CVI children with viral myocarditis; the second one was added the treatment of Huangqi Granules to the ill children; the third one was the normal control group． To determine the level of serum IFN － γ，IL － 4，cTnI，cTnT and examine children’s ECG were to indirectly understand the condition of Th1 /Th2 imbalance and impairment of heart muscles． Finally，improvements in recovering Th1 /Th2 balance and curative rate of myocarditis after treating by Huangqi Granules could be observed． Ｒesults: Before treatment，serum IFN － γlevels in the first and second group were lower than that in control group ( P ＜ 0． 05) ，IL － 4 levels higher than control group ( P ＜ 0． 05) ，and immunodominance tended to be Th2; after treated by Huangqi Granules，the second group showed that serum IFN － γlevels rose and IL － 4 levels decreased to the levels of the control group ( P ＞ 0． 05) and meanwhile Th1 /Th2 re- covered the balance; elimination coefficient of the abnormal ECG and negative － positive converting rate of cTnI and cTnT in the second group were higher than those in the first group( P ＜ 0． 01) ． Conclusion: The imbalance of Th1 /Th2 is the cause of this kind of myocarditis and the regulating effect of Huangqi Granules is great in increase its curative rate．

参考文献/References:

[1]潘晓波，孙景辉，高齐． 儿童病毒性心肌炎诊疗进展 ［J]． 中国实验诊断学，2014，18( 5) : 863 － 867．
[2]Elliott P，Anderson B，Arbustini E，et al． Classification of the cardiomyopathies: a position statement from the Eu- ropean Society of Cardiology Working Group on myocardial and pericardial diseases［J]． Eur Heart J，2008，29( 2) : 270 － 276．
[3]Chen ＲF，Yeh WT，Yang MY，et al． A model of the real time correlation of viral titers with immune reactions in an- tibody dependent enhancement of dengue － 2 infections ［J]． FEMS Immunol Med Microbiol，2001，30: 17．
[4]颜培宇，于晓红，张德山，等． 黄芪总黄酮对免疫功能 低下小鼠 T 细胞极化的影响［J]． 浙江中医药大学学 报，2008，32( 2) : 163 － 164．
[5]安欣，李惠萍，王归圣． 黄芪注射液联合清开灵注射液 治疗急性病毒性心肌炎疗效观察［J]． 现代中医药， 2007，27( 6) : 19 － 20．

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备注/Memo

备注/Memo:
收稿日期:2016－11－23编辑:杨芳艳
更新日期/Last Update: 2017-05-15