[1]孙建飞 张习禄 李展绒＊＊ 吴旭初 雷 霆 周 军.通腑活血方对大鼠术后肠粘连的影响[J].现代中医药,2017,(04):099-103.[doi:10.13424/j.cnki.mtcm.2017.04.036]
Sun Jianfei Zhang Xilu Li Zahnrong Wu Xuchu Lei Ting Zhou Jun.Influence of Tongfu Huoxue Prescription over Postoperative Intestinal Adhesion[J].Modern Traditional Chinese Medicine,2017,(04):099-103.[doi:10.13424/j.cnki.mtcm.2017.04.036]
点击复制
通腑活血方对大鼠术后肠粘连的影响(
)
《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]
- 卷:
-
- 期数:
-
2017年04期
- 页码:
-
099-103
- 栏目:
-
药物研究
- 出版日期:
-
2017-07-05
文章信息/Info
- Title:
-
Influence of Tongfu Huoxue Prescription over Postoperative Intestinal Adhesion
- 文章编号:
-
1672－0571(2017)04－0100－05
- 作者:
-
孙建飞1 张习禄1 李展绒1＊＊ 吴旭初2 雷 霆1 周 军1
-
1．陕西中医药大学附属医院，陕西 咸阳 712000; 2．咸宁市通城县人民医院，湖北 咸宁 437000
- Author(s):
-
Sun Jianfei1 Zhang Xilu1 Li Zahnrong1 Wu Xuchu2 Lei Ting1 Zhou Jun1
-
1． The Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，China; 2． People’s Hospital of Tongcheng County，Xianning 437000，China
-
- 关键词:
-
通腑活血方; 术后肠粘连; 白介素－6 ; 肿瘤坏死因子－α
- Keywords:
-
Tongfu Huoxue Prescription; postoperative intestinal adhesion; IL－6; TNF－α
- 分类号:
-
Ｒ285.5
- DOI:
-
10.13424/j.cnki.mtcm.2017.04.036
- 文献标志码:
-
A
- 摘要:
-
目的 通过制作术后肠粘连 SD 大鼠模型，证实通腑活血方能有效防治术后肠粘连的发生，并初步
探讨其作用机制。方法 SD 大鼠 40 只，随机分为 4 组，即正常组( n = 10) 、模型组( n = 10) 、大黄 虫丸组( n = 10) 和通腑活血方组( n = 10) ，术后第 7 天观察各组大鼠肠粘连等级，并采用 ELISA 法检测各组大鼠 IL－6、TNF－ α 血清浓度，同时在 X 线和 B 超下观察其肠腔扩张及血运情况。结果 大黄庶虫丸组和通腑活血方组肠粘连等
级均低于模型组( P＜0．05) ，且术后第 7 天血清 IL－6 和 TNF－α 水平均低于模型组( P＜0．01) ; X 线和 B 超观察发
现: 通腑活血方组较模型组肠管血供较好，肠管蠕动更频繁且肠腔积气明显减少。结论 通腑活血方能够降低血
清中 IL－6 和 TNF－α 水平、促进肠道蠕动、减轻肠管扩张，从而防治大鼠术后肠粘连的发生。
- Abstract:
-
Objective: To prove that Tongfu Huoxue Prescription can effectively prevent postoperative intestinal ad- hesion and primarily explore its mechanisms by preparing the SD rats model with postoperative intestinal adhesion． Meth- od: Totally 40 rats were randomly divided into 4 groups: normal，model，Dahuangchong Pill and Tongfu Huoxue Prescrip- tion group with equal numbers． On the 7th day after operation，the adhensive degrees in all groups were defined，the ser- um IL－6 and TNF－α concentrations were checked by ELISA and the conditions of intestinal distension as well as blood circulation were observed under X－ray and ultrasound． Ｒesults: The adhesive degrees in Dahuangchong Pill and Tongfu Huoxue Prescription group were lower than in the model group ( P＜0．05) and the IL－6 and TNF－α levels in these two groups were lower than the model group on the 7th day after operation ( P＜ 0．01) ． X－ray and ultrasound results: The blood circulation of Tongfu Huoxue Prescription group was better，the bowel movements were more frequent and air accu- mulating in the cavity significantly reduced，compared with the model group． Conclusion: Tongfu Huoxue Prescription is able to decrease the IL－6 and TNF－α levels，promote bowel movement and lighten intestinal distention to prevent the oc- currence of rats’postoperative intestinal adhesion．
参考文献/References:
[1]刘道生，王昆松，胡敏，等．肠浆膜完整性与肠粘连发生
关系的实验研究［J]．贵州医药，2005，29( 9) : 838－839．
[2]曾莉，颜帅，李文林．中医药抗腹腔粘连实验研究进展
［J]．南京中医药大学学报，2014，30( 1) : 93－96．
[3]Ellis H． The aetiology of postoperative abdominal adhesion: an experimental study［J]．Br J Surg，1962，50: 10－6．
[4]Hugh TB，Ellis H． Postoperative abdominal adhesion，An experiment study of the value of polyviny pyrrolidone in prophlaxis［J]．Br I Surq，1964，51 ( 5) : 381－382．
[5]曾健，李晓辉．腹膜粘连的分子机制及药物防治［J]．世
界华人消化杂志，2003，11( 9) : 1429－1432．
[6]孙建飞，雷霆，肖刚，等．通腑活血方对腹部手术后肠粘
连预防作用 的 临 床 研 究［J]． 现代中西医结合杂志， 2010，19( 17) : 2132－2133．
[7]张惜燕，田丙坤．活血化瘀法的临床应用［J]．现代中医
药，2015，35( 1) : 48－50．
[8]李宝贤，王勤．大承气汤加味治疗重症急性胰腺炎并发
麻痹性肠梗阻临床观察［J]．陕西中医学院学报，2015， 38( 1) : 35－36．
备注/Memo
- 备注/Memo:
-
收稿日期:2016－06－08编辑:文颖娟＊＊
基金项目:陕西省教育厅资助项目(2010JK514)
通讯作者:李展绒(1975－)，女，主管护师，研究方向:外科护理。E－mail:1342497530@qq．com
更新日期/Last Update:
2017-07-15