[1]杜永波** 杨建伟 王梅梅 徐新松王洪杰.基于心功能及氧化应激指标探析附萸汤 治疗慢性心力衰竭的有效性[J].现代中医药,2023,(05):074-79.[doi:10.13424/j.cnki.mtcm.2023.05.015]
　DU Yongbo YANG Jianwei WANG Meimei XU Xinsong WANG Hongjie.Effectiveness of Fuyu Decoction in Treating Chronic Heart Failure Based on Cardiac Function and Oxidative Stress Indicators[J].Modern Traditional Chinese Medicine,2023,(05):074-79.[doi:10.13424/j.cnki.mtcm.2023.05.015]
点击复制

基于心功能及氧化应激指标探析附萸汤 治疗慢性心力衰竭的有效性
分享到：

《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年05期
页码:
074-79
栏目:
出版日期:
2023-09-20

文章信息/Info

Title:
Effectiveness of Fuyu Decoction in Treating Chronic Heart Failure Based on Cardiac Function and Oxidative Stress Indicators
文章编号:
1672-0571(2023)05-0074-06
作者:
杜永波1** 杨建伟1 王梅梅1 徐新松1王洪杰2
1.汉中市中心医院/市中医医院,陕西 汉中 723100；
2.汉中市南郑区人民医院,陕西 汉中 723100
Author(s):
DU Yongbo1 YANG Jianwei1 WANG Meimei1 XU Xinsong1 WANG Hongjie2
1.Department of Geriatry，Hanzhong Central Hospital/Municipal Traditional Chinese Medicine Hospital, Shaanxi Hanzhong 723100,China；
2.Department of Cardiovascular Medicine， Nanzheng District Peoples Hospital，Shaanxi Hanzhong 723100,China
关键词:
关键词：心功能; 慢性心力衰竭; 附萸汤; 氧化应激; 随机对照
Keywords:
Key words:Cardiac function; Chronic heart failure; Fuyu decoction; Oxidative stress; Randomized controlled
分类号:
R256.2
DOI:
10.13424/j.cnki.mtcm.2023.05.015
文献标志码:
A
摘要:
摘 要：目的 观察附萸汤治疗慢性心力衰竭对患者心功能、氧化应激指标的影响。方法 收集汉中市中心医院2020年1月—2022年1月收治的慢性心力衰竭患者120例，随机分组为对照组（60例，常规西药治疗）、治疗组（60例，常规西药+附萸汤），评估疗效，记录患者治疗前及治疗后中医症状评分，测量治疗前及治疗后心功能指标、氧化应激指标，记录治疗期间不良反应发生情况。结果 治疗组总有效率显著高于对照组（P＜0.05）；治疗后治疗组主症积分、次症积分均显著低于对照组（P＜0.05）；治疗后治疗组左室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）及血清丙二醛（MDA）水平显著低于对照组（P＜0.05）；左心室射血分数（LVEF）及血清超氧化物歧化酶（SOD）水平显著高于对照组（P＜0.05）；组间不良反应发生率比较无显著差异（P＞0.05）。结论 给予慢性心力衰竭患者附萸汤治疗可显著下调患者氧化应激指标水平，改善临床症状及心功能，提升整体疗效，且联合治疗安全性高。
Abstract:
Abstract：Objective To explore the effects of Fuyu decoction on heart function and oxidative stress indicators in patients with chronic heart failure.Methods 120 patients with chronic heart failure admitted to Hanzhong Central Hospital from January 2020 to January 2022 were collected and randomly divided into a control group (60 cases，treated with conventional Western medicine) and a treatment group (60 cases，treated with conventional Western medicine+Fuyu decoction).The therapeutic effect was evaluated，and the scores of traditional Chinese medicine symptoms before and after treatment were recorded.Cardiac function indicators and oxidative stress indicators were measured before and after treatment，and the occurrence of adverse reactions during treatment was recorded.Results The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05)；After treatment，the main symptom score and secondary symptom score of the treatment group were significantly lower than those of the control group (P<0.05)；After treatment，the left ventricular end diastolic diameter (LVEDD)，left ventricular end systolic diameter (LVESD)，and serum malondialdehyde (MDA) levels in the treatment group were significantly lower than those in the control group (P<0.05)；The left ventricular ejection fraction (LVEF) and serum superoxide dismutase (SOD) levels were significantly higher than those in the control group (P<0.05)；There was no significant difference in the incidence of adverse reactions between groups (P>0.05).Conclusion Treating patients with chronic heart failure with Fuyu decoction can significantly lower the levels of oxidative stress indicators，improve clinical symptoms and heart function，enhance overall efficacy，and the combined treatment has high safety.

参考文献/References:

［1］张广平,谢华宁.从2018中国心衰诊疗指南看更新亮点［J］.陕西中医药大学学报,2020,43(1):40-42,61.
［2］冠心病中医临床研究联盟,中国中西医结合学会心血管疾病专业委员会,中华中医药学会心病分会,等.慢性心力衰竭中医诊疗专家共识［J］.中医杂志,2014,55(14):1258-1260.
［3］Li Y,Wu H,Zhang B,et al.Efficacy and safety of Linggui Zhugan decoction in the treatment of chronic heart failure with Yang deficiency:A protocol for systematic review and metaanalysis［J］.Medicine,2021,100(20):e26012.
［4］章燕,邓坤,李广兵,等.半夏白术天麻汤治疗痰湿内阻型原发性高血压合并慢性心力衰竭临床观察［J］.河北中医,2022,44(5):778-783.
［5］朱杰,林兆奋,胡聃,等.附萸汤对慢性心力衰竭患者心功能、心室重塑、NT-proBNP、H-FABP水平的影响［J］.现代中西医结合杂志,2021,30(2):200203.
［6］中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.慢性心力衰竭基层诊疗指南(2019年)［J］.中华全科医师杂志,2019,18(10):936-947.
［7］中国中西医结合学会心血管疾病专业委员会,中国医师协会中西医结合医师分会心血管疾病专业委员会.慢性心力衰竭中西医结合诊疗专家共识［J］.心脑血管病防治,2016,16(5):340-347.
［8］郑筱萸.中药新药临床研究指导原则［M］.北京：中国医药科技出版社,2002：23-28.
［9］沈绍功,王承德,闫希军.中医心病诊断疗效标准与用药规范［M］.北京：北京出版社,2002：47-52.
［10］高飞,付强,包书茵,等.中医药治疗慢性心力衰竭机制的研究进展［J］.中医药信息,2022,39(5):85-89.
［11］林琳,职利琴.芪甲五苓汤对慢性心力衰竭患者血清脑钠肽及心功能的影响［J］.现代中医药,2016,36(2):14-16.
［12］侯玉鸣,汤诺.芪附强心汤治疗心阳虚血瘀型冠心病慢性心力衰竭临床进展［J］.贵州医药,2022,46(9):1355-1356.
［13］张婷,职利琴.中西医结合治疗老年慢性心力衰竭28例［J］.现代中医药,2012,32(2):17-18.
［14］文建霞,王建,张璐,等.附子配伍干姜治疗心力衰竭的药理作用及机制研究进展［J］.中国医院用药评价与分析,2019,19(10):1167-1170.
［15］徐香玲,杨继,赵英强.附子温阳功效在治疗心力衰竭病中的临床应用进展［J］.现代中西医结合杂志,2021,30(31):3520-3525.
［16］邱清勇,彭锦,陈丽,等.山茱萸莫罗苷经Bcl-2/Bax通路抗H9c2心肌细胞氧化应激损伤研究［J］.中国药业,2020,29(17):39-43.
［17］李佳欣,陈思琦,葛鹏玲.山茱萸药理学研究进展［J］.辽宁中医药大学学报,2022,24(4):63-66.
［18］贾欢欢,曾业文,李航,等.附子与山茱萸配伍对慢性心力衰竭大鼠的影响［J］.中草药,2019,50(2):418-422.
［19］刘佳宝,张瑞英.心力衰竭时氧化应激与心肌代谢［J］.国际心血管病杂志,2022,49(2):89-91.
［20］陶延丽,许绍信,王琳.加味真武汤对心肾阳虚型慢性心力衰竭患者心肌纤维化、氧化应激、血管内皮功能及心肌能量代谢的影响［J］.中医药导报,2021,27(6):86-90.
［21］脱梅娟,韩琳,刘力,等.参芪定悸汤调控p38MAPK表达抑制慢性心力衰竭大鼠心肌的氧化损伤［J］.解剖学杂志,2022,45(2):116-120,129.
［22］高峰,肖雪,于策,等.益气通脉方对气虚血瘀型慢性心力衰竭患者心肌重塑、氧化应激及血管内皮功能的影响［J］.微循环学杂志,2022,32(2):40-44.
［23］庄华梅,陈秀娇,王俊芳,等.补骨脂对慢性心力衰竭大鼠心肌损伤的影响［J］.中西医结合心脑血管病杂志,2021,19(6):930-934.
［24］陈家显,刘先霞,陈跃武,等.芪参益气滴丸对慢性心力衰竭大鼠心肌细胞凋亡的抑制作用及其机制［J］.吉林大学学报（医学版）,2020,46(5):972-978.
［25］刘义刚,刘亚辉,刘力毓,等.瑞舒伐他汀对慢性心力衰竭患者血脂、炎性因子及血清SOD、MDA水平的影响［J］.实用临床医药杂志,2016,20(9):142-144.

相似文献/References:

[1]唐婉莹.益气活血利水法治疗慢性心力衰竭的疗效观察[J].现代中医药,2019,(05):058.[doi:10.13424/j.cnki.mtcm.2019.05.018]
[2]夏柔娟 蒙广阔 *.心衰合剂治疗慢性心力衰竭临床疗效观察[J].现代中医药,2018,(06):009.[doi:10.13424/j.cnki.mtcm.2018.06.004]
　Xia Roujuan Meng Guangkuo.Clinical Observation of Heart Failure Mixture in Treating Chronic Heart Failure[J].Modern Traditional Chinese Medicine,2018,(05):009.[doi:10.13424/j.cnki.mtcm.2018.06.004]
[3]杨嘉豪 徐建虎.温阳消饮法对慢性心力衰竭模型 大鼠血清 ＡＮＰ、ＴＮＦ－α及 ＩＬ－６水平影响[J].现代中医药,2019,(02):092.[doi:10.13424/j.cnki.mtcm.2019.02.028]
　Yang Jiahao Xu Jianhu.Effect of the Therapy of Warming Yang to Resolve Fluid Retention on Serum ANP, TNF -α and IL -6 Levels in Rats with Chronic Heart Failure[J].Modern Traditional Chinese Medicine,2019,(05):092.[doi:10.13424/j.cnki.mtcm.2019.02.028]
[4]田 心.从中医“圆运动”谈慢性心力衰竭诊疗指南的药物应用[J].现代中医药,2021,(02):018.[doi:10.13424/j.cnki.mtct.2021.02.004]
　TIAN Xin.Discussion on Drug Application of Chronic Heart Failure Diagnosis and Treatment Guidelines from circular movement of Chinese Medicine[J].Modern Traditional Chinese Medicine,2021,(05):018.[doi:10.13424/j.cnki.mtct.2021.02.004]
[5]张军茹.中西医视角治疗慢性心力衰竭合并高尿酸血症探析[J].现代中医药,2021,(03):001.[doi:10.13424/j.cnki.mtcm.2021.03.001]
　ZHANGJunru.TreatmentofChronicHeartFailurewithHyperuricemiafromthePerspectiveofTraditionalChineseandWesternMedicine[J].Modern Traditional Chinese Medicine,2021,(05):001.[doi:10.13424/j.cnki.mtcm.2021.03.001]
[6]王铭马立旭 王秀萍韩金荣 徐建虎.消饮化瘀方对慢性心力衰竭大鼠NTproBNP及GPR35mRNA水平的影响[J].现代中医药,2023,(05):113.[doi:10.13424/j.cnki.mtcm.2023.05.021]

备注/Memo

备注/Memo:
基金项目：陕西省社会发展科技攻关项目（2016SF224）
更新日期/Last Update: 2023-09-22